HIC2 - HIC ZBTB transcriptional repressor 2 Gene

Homo sapiens

Also known as HRG22; ZBTB30; ZNF907

Gene ID: 23119 | Gene type: protein coding

About HIC2

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,417,371-21,451,463 (from NCBI)

This gene has 3 transcripts (splice variants), 187 orthologues and 36 paralogues. Broad expression in placenta (RPKM 3.4), testis (RPKM 2.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HIC2 Products(1)

mRNA	Protein	Name
NM_015094.3	NP_055909.2	hypermethylated in cancer 2 protein

HIC2 Protein Structure

BTB

zf-C2H2_4

zf-C2H2

zf-H2C2_2

0
100
200
300
400
500
615 a.a.

Protein Preferred Names

Protein Names

hypermethylated in cancer 2 protein

HIC1-related gene on chromosome 22 protein

Related Diseases

Diseases

Alias

Orofaciodigital Syndrome X

OFD10	Orofaciodigital Syndrome With Fibular Aplasia
Oral-Facial-Digital Syndrome With Fibular Aplasia	Ofds X
Oral-Facial-Digital Syndrome, Type X	Orofaciodigital Syndrome 10
Ofd Syndrome 10	Ofds 10
Oral Facial Digital Syndrome 10	Oral Facial Digital Syndrome Type 10
Oral-Facial-Digital Syndrome 10	Orofaciodigital Syndrome Type Figuera
Orofaciodigital Syndrome Type 10	Figuera Syndrome
Oral-Facial-Digital Syndrome Type 10

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome	DGS
Hypoplasia Of Thymus And Parathyroids	Third And Fourth Pharyngeal Pouch Syndrome
22q11.2 Deletion Syndrome	Digeorge Sequence
Digeorge'S Syndrome	Pharyngeal Pouch Syndrome
Di-George Syndrome	Shprintzen Syndrome

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1	Simpson-Golabi-Behmel Syndrome
SGBS1	Golabi-Rosen Syndrome
Simpson Dysmorphia Syndrome	Sgbs
Bulldog Syndrome	Dgsx
Sdys	Dysplasia Gigantism Syndrome, X-Linked
X-Linked Dysplasia Gigantism Syndrome	Dgsx Golabi-Rosen Syndrome
Sara Angers Syndrome	Sgb Syndrome
Mental Retardation-Overgrowth Syndrome	Simpson Dysplasia Syndrome
Simpson Syndrome	Simpson-Golabi-Behmel Syndrome 1
Dysplasia Gigantism Syndrome X-Linked

Van Den Ende-Gupta Syndrome

VDEGS	Blepharophimosis, Arachnodactyly, And Congenital Contractures
Marden-Walker-Like Syndrome	Marden-Walker-Like Syndrome Without Psychomotor Retardation
Marden Walker Like Syndrome	Marden-Walker-Like Syndrome Without Psychmotor Retardation
Van Den Ende Gupta Syndrome	Marden Walker Like Syndrome Without Psychomotor Retardation
Blepharophimosis Arachnodactyly And Congenital Contractures

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06166	HIC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HIC2	VGNC	VGNC:82156
Bos taurus	HIC2	VGNC	VGNC:29846
Mus musculus	HIC2	MGD	MGI:1929869
Canis familiaris	HIC2	VGNC	VGNC:41684
Rattus norvegicus	HIC2	RGD	RGD:1305338
Felis catus	HIC2	VGNC	VGNC:62812