ZNF3 - zinc finger protein 3 Gene

Also Known as A8-51; HF.12; KOX25; PP838; Zfp113

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7551

About ZNF3

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,063,837-100,082,577 (from NCBI)

This gene has 15 transcripts (splice variants), 178 orthologues and 174 paralogues. Ubiquitous expression in endometrium (RPKM 7.6), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF3 Products (22)

mRNA Protein Name
NM_001278284.2 NP_001265213.1 zinc finger protein 3 isoform 2
NM_001278287.2 NP_001265216.1 zinc finger protein 3 isoform 2
NM_001278290.2 NP_001265219.1 zinc finger protein 3 isoform 2
NM_001278291.2 NP_001265220.1 zinc finger protein 3 isoform 3
NM_001278292.2 NP_001265221.1 zinc finger protein 3 isoform 3
NM_001318135.2 NP_001305064.1 zinc finger protein 3 isoform 2
NM_001318136.2 NP_001305065.1 zinc finger protein 3 isoform 4
NM_001318137.2 NP_001305066.1 zinc finger protein 3 isoform 5
NM_001362775.2 NP_001349704.1 zinc finger protein 3 isoform 4
NM_001362776.2 NP_001349705.1 zinc finger protein 3 isoform 6
NM_001362777.2 NP_001349706.1 zinc finger protein 3 isoform 3
NM_001371210.1 NP_001358139.1 zinc finger protein 3 isoform 1
NM_001371211.1 NP_001358140.1 zinc finger protein 3 isoform 2
NM_001371212.1 NP_001358141.1 zinc finger protein 3 isoform 2
NM_001371213.1 NP_001358142.1 zinc finger protein 3 isoform 2
NM_001371214.1 NP_001358143.1 zinc finger protein 3 isoform 2
NM_001371215.1 NP_001358144.1 zinc finger protein 3 isoform 3
NM_001371216.1 NP_001358145.1 zinc finger protein 3 isoform 3
NM_001371217.1 NP_001358146.1 zinc finger protein 3 isoform 4
NM_001371218.1 NP_001358147.1 zinc finger protein 3 isoform 7
NM_017715.4 NP_060185.2 zinc finger protein 3 isoform 1
NM_032924.5 NP_116313.3 zinc finger protein 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18255255 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18255255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF3 Protein Structure

KRAB

KRAB: KRAB box (51 - 91)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (215 - 238)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (243 - 266)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (273 - 294)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (299 - 323)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (330 - 350)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (354 - 379)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (383 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 446 a.a.
Protein Preferred Names Protein Names

zinc finger protein 3

  • C2-H2 type zinc finger protein

ZNF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF3 P17036 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
ZNF3 P17036 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
ZNF3 P17036 ZNF212 Homo sapiens Q9UDV6
Y2H
18255255
Intra
ZNF3 P17036 ZNF212 Homo sapiens Q9UDV6
Pull Down
18255255
Intra
ZNF3 P17036 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
ZNF3 P17036 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
32296183
Intra
ZNF3 P17036 MCC Homo sapiens P23508
Validated Y2H
32296183
Intra
ZNF3 P17036 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
25416956
Intra
ZNF3 P17036 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ZNF3 P17036 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
ZNF3 P17036 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
ZNF3 P17036 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra
ZNF3 P17036 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
25416956
Intra
ZNF3 P17036 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra
ZNF3 P17036 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
ZNF3 P17036 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 MCC Homo sapiens P23508
Y2H Array
32296183
Intra
ZNF3 P17036 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra
ZNF3 P17036 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
ZNF3 P17036 SF3B4 Homo sapiens Q15427
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 SF3B4 Homo sapiens Q15427
Validated Y2H
32296183
Intra
ZNF3 P17036 SF3B4 Homo sapiens Q15427
Y2H Array
32296183
Intra
ZNF3 P17036 YJU2B Homo sapiens P13994
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 YJU2B Homo sapiens P13994
Y2H Array
32296183
Intra
ZNF3 P17036 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra
ZNF3 P17036 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
32296183
Intra
ZNF3 P17036 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153698 CC-3060 99.7% Unkown
HY-RS16123 ZNF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF3 MGD MGI:1929116
Rattus norvegicus ZNF3 RGD RGD:6489147
Macaca mulatta ZNF3 VGNC VGNC:81889
Bos taurus ZNF3 VGNC VGNC:37241
Others ZNF3 NCBI