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GPSM3 - G protein signaling modulator 3 Gene

Also Known as G18; NG1; AGS4; G18.2; C6orf9; G18.1a; G18.1b

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63940

About GPSM3

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,190,766-32,195,523 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 162 orthologues and 6 paralogues. Broad expression in spleen (RPKM 56.7), lymph node (RPKM 55.9) and 21 other tissues.

Summary

Predicted to enable GTPase regulator activity. Predicted to be involved in positive regulation of inflammatory response. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response and positive regulation of leukocyte chemotaxis. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPSM3 Products (2)

mRNA	Protein	Name
NM_001276501.2	NP_001263430.1	G-protein-signaling modulator 3
NM_022107.3	NP_071390.1	G-protein-signaling modulator 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPSM3 Protein Structure

GoLoco

0
100
160 a.a.

Protein Preferred Names	Protein Names
G-protein-signaling modulator 3	G-protein signaling modulator 3 (AGS3-like, C. elegans)

GPSM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPSM3	Q9Y4H4	P4HA3	Homo sapiens	Q7Z4N8	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	P4HA3	Homo sapiens	Q7Z4N8	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	GPSM3	Q9Y4H4	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	GPSM3	Q9Y4H4	STXBP5L	Homo sapiens	Q9Y2K9	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	STXBP5L	Homo sapiens	Q9Y2K9	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	HELT	Homo sapiens	A0A087WSW0	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	HELT	Homo sapiens	A0A087WSW0	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	SPRY3	Homo sapiens	O43610	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	SPRY3	Homo sapiens	O43610	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ASB15	Homo sapiens	Q8WXK1	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ASB15	Homo sapiens	Q8WXK1	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	ACMSD	Homo sapiens	Q8TDX5-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ACMSD	Homo sapiens	Q8TDX5-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	KCNJ5-AS1	Homo sapiens	Q8TAV5	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	KCNJ5-AS1	Homo sapiens	Q8TAV5	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	RSPO4	Homo sapiens	Q2I0M5	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	RSPO4	Homo sapiens	Q2I0M5	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	SPMIP5	Homo sapiens	Q8WW14-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	SPMIP5	Homo sapiens	Q8WW14-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	FAM86C1P	Homo sapiens	Q9NVL1-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	RIPK4	Homo sapiens	P57078-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	RIPK4	Homo sapiens	P57078-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	HIGD2B	Homo sapiens	Q4VC39	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	HIGD2B	Homo sapiens	Q4VC39	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	PRR5	Homo sapiens	P85299-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	PRR5	Homo sapiens	P85299-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	KRTAP19-4	Homo sapiens	Q3LI73	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	KRTAP19-4	Homo sapiens	Q3LI73	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ANKRD33	Homo sapiens	Q7Z3H0-1	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	C9orf57	Homo sapiens	Q5W0N0-2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	C9orf57	Homo sapiens	Q5W0N0-2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	IVD	Homo sapiens	P26440	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	IVD	Homo sapiens	P26440	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	GPSM3	Q9Y4H4	YWHAZ	Homo sapiens	P63104	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	YWHAZ	Homo sapiens	P63104	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	GPSM3	Q9Y4H4	GNAI2	Homo sapiens	P04899	Y2H Array	25416956
Intra	GPSM3	Q9Y4H4	GNAI3	Homo sapiens	P08754	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	GNAI3	Homo sapiens	P08754	Y2H Prey Pooling	25416956
Intra	GPSM3	Q9Y4H4	GNAI3	Homo sapiens	P08754	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	IQCE	Homo sapiens	Q6IPM2	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	IQCE	Homo sapiens	Q6IPM2	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	NR0B2	Homo sapiens	Q15466	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	NR0B2	Homo sapiens	Q15466	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	BMF	Homo sapiens	Q96LC9	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	BMF	Homo sapiens	Q96LC9	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Y2H Prey Pooling	25416956
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Validated Y2H	25416956
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Anti Tag CoIP	33961781
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	GNAI1	Homo sapiens	P63096	Y2H Array	25416956
Intra	GPSM3	Q9Y4H4	COA7	Homo sapiens	Q96BR5	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	COA7	Homo sapiens	Q96BR5	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	ZNF20	Homo sapiens	P17024	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ZNF20	Homo sapiens	P17024	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	GPSM3	Q9Y4H4	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	25416956
Intra	GPSM3	Q9Y4H4	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	GPSM3	Q9Y4H4	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	GPSM3	Q9Y4H4	TADA2A	Homo sapiens	O75478	Y2H Array	25416956
Intra	GPSM3	Q9Y4H4	BATF2	Homo sapiens	Q8N1L9	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	BATF2	Homo sapiens	Q8N1L9	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ZNF581	Homo sapiens	Q9P0T4	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	ZNF581	Homo sapiens	Q9P0T4	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	GPSM3	Q9Y4H4	GATAD2B	Homo sapiens	Q8WXI9	Y2H Array	32296183
Intra	GPSM3	Q9Y4H4	GATAD2B	Homo sapiens	Q8WXI9	Y2H Prey Pooling	32296183
Intra	GPSM3	Q9Y4H4	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	GPSM3	Q9Y4H4	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	GPSM3	Q9Y4H4	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Prostate Leiomyosarcoma	Leiomyosarcoma Of The Prostate
Hypermobility Of Coccyx	Coccygeal Hypermobility Syndrome Hypermobility Of The Coccyx
Klippel-Feil Syndrome 3
Prostate Sarcoma	Sarcoma Of The Prostate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05761	GPSM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPSM3	RGD	RGD:1303014
Felis catus	GPSM3	VGNC	VGNC:62699
Canis familiaris	GPSM3	VGNC	VGNC:41459
Macaca mulatta	GPSM3	VGNC	VGNC:72938
Mus musculus	GPSM3	MGD	MGI:2146785
Others	GPSM3	NCBI