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COA7 - cytochrome c oxidase assembly factor 7 Gene

Also Known as RESA1; SCAN3; SELRC1; C1orf163

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65260

About COA7

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,684,449-52,698,347 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 6.1), colon (RPKM 6.0) and 25 other tissues.

Summary

Located in mitochondrial intermembrane space and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

COA7 Products (1)

mRNA	Protein	Name
NM_023077.3	NP_075565.2	cytochrome c oxidase assembly factor 7

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30885959	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	30885959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COA7 Protein Structure

Sel1

0
100
200
231 a.a.

Protein Preferred Names	Protein Names
cytochrome c oxidase assembly factor 7	Sel1 repeat containing 1

COA7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COA7	Q96BR5	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	COA7	Q96BR5	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	COA7	Q96BR5	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	COA7	Q96BR5	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
Intra	COA7	Q96BR5	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
Intra	COA7	Q96BR5	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
Intra	COA7	Q96BR5	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	COA7	Q96BR5	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	COA7	Q96BR5	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	COA7	Q96BR5	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
Intra	COA7	Q96BR5	RAN	Homo sapiens	P62826	Validated Y2H	32814053
Intra	COA7	Q96BR5	RAN	Homo sapiens	P62826	Y2H Array	32814053
Intra	COA7	Q96BR5	GPSM3	Homo sapiens	Q9Y4H4	Validated Y2H	32296183
Intra	COA7	Q96BR5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	COA7	Q96BR5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	COA7	Q96BR5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	COA7	Q96BR5	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	COA7	Q96BR5	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	COA7	Q96BR5	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	COA7	Q96BR5	CYCS	Homo sapiens	P99999	Y2H Pooling	32814053
Intra	COA7	Q96BR5	CYCS	Homo sapiens	P99999	Validated Y2H	32814053
Intra	COA7	Q96BR5	CYCS	Homo sapiens	P99999	Y2H Array	32814053
Intra	COA7	Q96BR5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	COA7	Q96BR5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	COA7	Q96BR5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	COA7	Q96BR5	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	COA7	Q96BR5	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	COA7	Q96BR5	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	COA7	Q96BR5	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
Intra	COA7	Q96BR5	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
Intra	COA7	Q96BR5	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
Intra	COA7	Q96BR5	HMOX2	Homo sapiens	P30519	Y2H Array	32814053
Intra	COA7	Q96BR5	HMOX2	Homo sapiens	P30519	Y2H Pooling	32814053
Intra	COA7	Q96BR5	HMOX2	Homo sapiens	P30519	Validated Y2H	32814053
Intra	COA7	Q96BR5	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
Intra	COA7	Q96BR5	CASP6	Homo sapiens	P55212	Y2H Array	32814053
Intra	COA7	Q96BR5	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
Intra	COA7	Q96BR5	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 3	SCAN3
Axonal Neuropathy
Neuronopathy, Distal Hereditary Motor, Type Iib	HMN2B Hmn Iib Neuropathy, Distal Hereditary Motor, Type Iib Dhmn2b Distal Hereditary Motor Neuropathy Type 2b Distal Hereditary Motor Neuropathy Type Iib Neuronopathy, Distal Hereditary Motor, Type 2b Neuronopathy, Distal Hereditary Motor, 2b Dhmn Ii Neuropathy, Motor, Distal, Hereditary, Type 2b
Mitochondrial Complex Ii Deficiency	Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency Isolated Succinate-Coenzyme Q Reductase Deficiency Isolated Succinate-Coq Reductase Deficiency Isolated Succinate-Ubiquinone Reductase Deficiency Mitochondrial Respiratory Chain Complex Ii Deficiency Complex 2 Mitochondrial Respiratory Chain Deficiency Succinate Coq Reductase Deficiency Succinate Dehydrogenase Deficiency Isolated Succinate Dehydrogenase Deficiency Succinate-Coenzyme Q Reductase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear Type 1	Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency Cox Deficiency Cytochrome-C Oxidase Deficiency Disease MC1DN4 Cytochrome-C Oxidase Deficiency MC4DN1 Mitochondrial Complex I Deficiency, Nuclear Type 4 Complex 4 Mitochondrial Respiratory Chain Deficiency Complex Iv Deficiency Mitochondrial Complex 1 Deficiency, Nuclear Type 4 Nuclear Type Mitochondrial Complex I Deficiency 4 Deficiency Of Mitochondrial Respiratory Chain Complex4 MT-C4D Complex Iv Mitochondrial Respiratory Chain Deficiency Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-CE01336	7-Methylpentadecanoyl-CoA		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-CE00365	(7Z)-3-Oxohexadecenoyl-CoA		/	Unkown
HY-CE00367	(7Z)-Hexadecenoyl-CoA		/	Unkown
HY-CE00397	(R)-2-Hydroxyhexadecanoyl-CoA free acid		/	Unkown
HY-CE00398	(7Z,10Z)-Hexadecadienoyl-CoA		/	Unkown
HY-CE00404	(7Z,10Z,13Z)-Docosatrienoyl-CoA		/	Unkown
HY-CE00414	(7Z,10Z,13Z,16Z)-3-Oxodocosatetraenoyl-CoA		/	Unkown
HY-CE00419	(7Z,10Z,13Z,16Z,19Z)-3-Oxodocosapentaenoyl-CoA		/	Unkown
HY-CE00421	(7Z,10Z,13Z,16Z,19Z)-Docosapentaenoyl-CoA		/	Unkown
HY-CE01248	C7:0-CoA		/	Unkown
HY-CE01322	7-Hydroxytetradecanedioyl-CoA		/	Unkown
HY-CE01323	7-Hydroxyundecanoyl-CoA		/	Unkown
HY-CE01324	7-Methyl-3-oxo-6-octenoyl-CoA		/	Unkown
HY-CE01325	7-Methyl-3-oxooctanoyl-CoA		/	Unkown
HY-CE01326	7-MethylHexadecanoyl-CoA		/	Unkown
HY-CE01327	7-Methyldecanoyl-CoA		/	Unkown
HY-CE01328	7-Methyldocosanoyl-CoA		/	Unkown
HY-CE01329	7-Methyldodecanoyl-CoA		/	Unkown
HY-CE01330	7-Methylhenicosanoyl-CoA		/	Unkown
HY-CE01331	7-Methylheptadecanoyl-CoA		/	Unkown
HY-CE01332	7-Methylicosanoyl-CoA		/	Unkown
HY-CE01333	7-Methylnonanoyl-CoA		/	Unkown
HY-CE01334	7-Methyloctadecanoyl-CoA		/	Unkown
HY-CE01335	7-Methylpentacosanoyl-CoA		/	Unkown
HY-CE01337	7-Methyltetracosanoyl-CoA		/	Unkown
HY-CE01338	7-Methyltetradecanoyl-CoA		/	Unkown
HY-CE01339	7-Methyltricosanoyl-CoA		/	Unkown
HY-CE01340	7-Methyltridecanoyl-CoA		/	Unkown
HY-CE01341	7-Methylundecanoyl-CoA		/	Unkown
HY-CE01342	7-Oxodecanoyl-CoA		/	Unkown
HY-CE01343	7-Oxononanoyl-CoA		/	Unkown
HY-CE01350	7-Hydroxyhexadecanedioyl-CoA		/	Unkown
HY-CE01351	7-Hydroxyhexadecanoyl-CoA		/	Unkown
HY-CE01352	7-Hydroxyoctadecanoyl-CoA		/	Unkown
HY-CE01353	7-Hydroxyoctanoyl-CoA		/	Unkown
HY-CE01354	7-Methylnonadecanoyl-CoA		/	Unkown
HY-CE01355	7-Methyloctanoyl-CoA		/	Unkown
HY-CE01357	7-Oxooctanoyl-CoA		/	Unkown
HY-CE01441	7-Hydroxydecanoyl-CoA		/	Unkown
HY-RS02944	COA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	COA7	VGNC	VGNC:53859
Felis catus	COA7	VGNC	VGNC:107512
Macaca mulatta	COA7	VGNC	VGNC:99870
Rattus norvegicus	COA7	RGD	RGD:1305274
Mus musculus	COA7	MGD	MGI:1917143
Canis familiaris	COA7	VGNC	VGNC:54197
Others	COA7	NCBI