SPRY3 - sprouty RTK signaling antagonist 3 Gene

Homo sapiens

Also known as spry-3

Gene ID: 10251 | Gene type: protein coding

About SPRY3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,612,586-155,782,459 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Involved in negative regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SPRY3 Products(5)

mRNA	Protein	Name
NM_001304990.2	NP_001291919.1	protein sprouty homolog 3
NM_001394353.1	NP_001381282.1	protein sprouty homolog 3
NM_001394354.1	NP_001381283.1	protein sprouty homolog 3
NM_001394355.1	NP_001381284.1	protein sprouty homolog 3
NM_005840.4	NP_005831.1	protein sprouty homolog 3

SPRY3 Protein Structure

Sprouty

0
100
200
288 a.a.

Protein Preferred Names

Protein Names

protein sprouty homolog 3

antagonist of FGF signaling

Related Diseases

Diseases

Alias

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome	Nfls
LGSS	Neurofibromatosis 1-Like Syndrome
Neurofibromatosis Type 1 Like Syndrome	Nf1-Like Syndrome
Neurofibromatosis, Type 1-Like Syndrome

Intellectual Developmental Disorder, X-Linked 108

MRX108	X-Linked Intellectual Developmental Disorder 108
Mental Retardation, X-Linked 108	Mental Retardation, X-Linked, Type 108

Colorblindness, Partial, Protan Series

Protanopia	Red Color Blindness
Protan Defect	CBP
Red Colorblindness	Colorblindness, Protan
Color Blindness, Red

Red-Green Color Blindness

Deutan Defect	Deuteranopia
Reduced Red-Green Discrimination	Color Blindness, Red-Green
Colorblindness, Partial, Deutan Series

Multiminicore Disease

Multiminicore Myopathy	Mmd
Minicore Disease	Minicore Myopathy
Multi-Core Congenital Myopathy	Multi-Core Disease
Multi-Minicore Disease	Multicore Disease
Multicore Myopathy	Minicore Myopathy With External Ophthalmoplegia

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13723	SPRY3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SPRY3	VGNC	VGNC:65651
Mus musculus	SPRY3	MGD	MGI:1345188
Bos taurus	SPRY3	VGNC	VGNC:35243
Rattus norvegicus	SPRY3	RGD	RGD:1562172

Name
Email *

	Sorry, but the email address you supplied was invalid.