MAPKBP1 - mitogen-activated protein kinase binding protein 1 Gene

Also Known as JNKBP1; NPHP20; JNKBP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23005

About MAPKBP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,774,484-41,827,855 (from NCBI)

This gene has 17 transcripts (splice variants), 121 orthologues, 26 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 16.2), skin (RPKM 11.0) and 23 other tissues.

Summary

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in Bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream Antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

MAPKBP1 Products (3)

mRNA Protein Name
NM_001128608.2 NP_001122080.1 mitogen-activated protein kinase-binding protein 1 isoform b
NM_001265611.2 NP_001252540.1 mitogen-activated protein kinase-binding protein 1 isoform c
NM_014994.3 NP_055809.2 mitogen-activated protein kinase-binding protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22700971 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22700971 GOA
involved in negative regulation of defense response to bacterium IMP
IMP: Inferred from mutant phenotype
22700971 GOA
involved in negative regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
22700971 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28089251 GOA
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
28089251 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKBP1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (82 - 108)

WD40

WD40: WD domain, G-beta repeat (126 - 163)

WD40

WD40: WD domain, G-beta repeat (178 - 203)

WD40

WD40: WD domain, G-beta repeat (285 - 306)

WD40

WD40: WD domain, G-beta repeat (388 - 427)

WD40

WD40: WD domain, G-beta repeat (481 - 505)

WD40

WD40: WD domain, G-beta repeat (517 - 550)

WD40

WD40: WD domain, G-beta repeat (559 - 594)

WD40

WD40: WD domain, G-beta repeat (693 - 730)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1514 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase-binding protein 1

  • JNK-binding protein 1

MAPKBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra
MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Intra
MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
MAPKBP1 O60336 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra
MAPKBP1 O60336 RGS20 Homo sapiens O76081-6
Y2H Array
25416956
Intra
MAPKBP1 O60336 ALG13 Homo sapiens Q9NP73-4
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 ALG13 Homo sapiens Q9NP73-4
Validated Y2H
25416956
Intra
MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Validated Y2H
32296183
Intra
MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRT38 Homo sapiens O76015
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
MAPKBP1 O60336 FOXN1 Homo sapiens O15353
Y2H Array
32296183
Intra
MAPKBP1 O60336 FOXN1 Homo sapiens O15353
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Validated Y2H
32296183
Intra
MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra
MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Y2H Array
32296183
Intra
MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Validated Y2H
32296183
Intra
MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 ADAM12 Homo sapiens O43184-4
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 ADAM12 Homo sapiens O43184-4
Y2H Array
32296183
Intra
MAPKBP1 O60336 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra
MAPKBP1 O60336 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
Intra
MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
Intra
MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
Intra
MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Validated Y2H
32296183
Intra
MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra
MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra
MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
MAPKBP1 O60336 MYOG Homo sapiens P15173
Validated Y2H
32296183
Intra
MAPKBP1 O60336 MYOG Homo sapiens P15173
Y2H Array
32296183
Intra
MAPKBP1 O60336 MYOG Homo sapiens P15173
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra
MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra
MAPKBP1 O60336 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
MAPKBP1 O60336 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
MAPKBP1 O60336 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra
MAPKBP1 O60336 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra
MAPKBP1 O60336 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
Intra
MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra
MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra
MAPKBP1 O60336 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra
MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra
MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra
MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
25416956
Intra
MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra
MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra
MAPKBP1 O60336 q7z783_human Homo sapiens Q7Z783
Y2H Array
25416956
Intra
MAPKBP1 O60336 q7z783_human Homo sapiens Q7Z783
Validated Y2H
25416956
Intra
MAPKBP1 O60336 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
MAPKBP1 O60336 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
MAPKBP1 O60336 KRT86 Homo sapiens O43790
Y2H Array
32296183
Intra
MAPKBP1 O60336 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephronophthisis 20

  • NPHP20
Late-Onset Nephronophthisis
Juvenile Nephronophthisis

  • Nephronophthisis

  • Nephronophthisis, Familial Juvenile
Nephronophthisis

  • Medullary Cystic Disease

  • Medullary Cystic Kidney

  • Nph

  • Nphp

  • Kidney Disease, Cystic, Medullary
Nephronophthisis 7

  • NPHP7

  • Nephronophthisis, Type 7
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1

  • Nevo Syndrome

  • Eds Vi

  • Ehlers-Danlos Syndrome, Type Vi

  • Eds Via

  • Ehlers-Danlos Syndrome Type 6

  • EDSKSCL1

  • Eds6

  • Ehlers-Danlos Syndrome Kyphoscoliotic Type 1

  • Kyphoscoliotic Ehlers-Danlos Syndrome

  • Cutis Hyperelastica

  • Ehlers-Danlos Syndrome Type 6a

  • Ehlers-Danlos Syndrome Oculoscoliotic Type

  • Kyphoscoliotic Eds

  • Kyphoscoliotic Eds Due To Lysyl Hydroxylase 1 Deficiency

  • Kyphoscoliotic Ehlers-Danlos Syndrome Due To Lysyl Hydroxylase 1 Deficiency

  • Lysyl Hydroxylase-Deficient Eds

  • Ocular-Scoliotic Eds

  • Keds

  • Keds-Plod1

  • Ehlers-Danlos Syndrome, Kyphoscoliotic Type 1

  • Ehlers-Danlos Syndrome, Ocular-Scoliotic Type

  • Ehlers-Danlos Syndrome, Type Via, Formerly

  • Eds6a, Formerly

  • Eds 6

  • Eds, Kyphoscoliotic Type

  • Eds, Oculoscoliotic Type

  • Ehlers-Danlos Syndrome, Kyphoscoliosis Type

  • Ehlers-Danlos Syndrome, Kyphoscoliotic Type

  • Ehlers-Danlos Syndrome, Oculoscoliotic Type

  • Eds6a

  • Ehlers-Danlos Syndrome 6

  • Ehlers-Danlos Syndrome Kyphoscoliotic Type
Interstitial Nephritis

  • Nephritis, Interstitial

  • Renal Tubulo-Interstitial Disease

  • Nephritis Interstitial

  • Nephritis, Tubulointerstitial
Nephronophthisis 16

  • NPHP16

  • Nephronophthisis, Type 16
Nephronophthisis 14

  • Joubert Syndrome 19

  • NPHP14

  • JBTS19

  • Nephronophthisis, Type 14
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Primary Autosomal Recessive Microcephaly

  • Autosomal Recessive Primary Microcephaly

  • Mcph

  • True Microcephaly

  • Microcephalia Vera

  • Microcephaly Vera

  • Microcephaly Primary Hereditary

  • Microcephaly, Primary, Autosomal Recessive

  • Primary Microcephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08136 MAPKBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MAPKBP1 VGNC VGNC:43009
Rattus norvegicus MAPKBP1 RGD RGD:1307578
Mus musculus MAPKBP1 MGD MGI:1347004
Bos taurus MAPKBP1 VGNC VGNC:31231
Macaca mulatta MAPKBP1 VGNC VGNC:74613
Others MAPKBP1 NCBI