KRT86 - keratin 86 Gene

Also Known as HB6; Hb1; K86; MNX; KRTHB1; KRTHB6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3892

About KRT86

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,274,645-52,309,163 (from NCBI)

This gene has 3 transcripts (splice variants), 44 orthologues, 68 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016]

KRT86 Products (1)

mRNA	Protein	Name
NM_001320198.2	NP_001307127.1	keratin, type II cuticular Hb6

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in keratin filament	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT86 Protein Structure

Filament

0
100
200
300
400
486 a.a.

Protein Preferred Names	Protein Names
keratin, type II cuticular Hb6	hair keratin K2.11

KRT86 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT86	O43790	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT86	O43790	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT86	O43790	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	KRT86	O43790	RTP5	Homo sapiens	Q14D33	Validated Y2H	32296183
Intra	KRT86	O43790	OLIG3	Homo sapiens	Q7RTU3	Validated Y2H	32296183
Intra	KRT86	O43790	ODF1	Homo sapiens	Q14990	Validated Y2H	32296183
Intra	KRT86	O43790	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	KRT86	O43790	KRT32	Homo sapiens	Q14532	Y2H Array	32296183
Intra	KRT86	O43790	KRT32	Homo sapiens	Q14532	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT32	Homo sapiens	Q14532	Validated Y2H	32296183
Intra	KRT86	O43790	KRT37	Homo sapiens	O76014	Validated Y2H	32296183
Intra	KRT86	O43790	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT86	O43790	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT86	O43790	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT34	Homo sapiens	O76011	Validated Y2H	32296183
Intra	KRT86	O43790	KRT38	Homo sapiens	O76015	Validated Y2H	32296183
Intra	KRT86	O43790	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT86	O43790	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT86	O43790	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT86	O43790	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT86	O43790	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT86	O43790	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	KRT86	O43790	CAMK2B	Homo sapiens	Q13554-3	Validated Y2H	32296183
Intra	KRT86	O43790	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KRT86	O43790	CEP57	Homo sapiens	Q86XR8-3	Validated Y2H	32296183
Intra	KRT86	O43790	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT39	Homo sapiens	Q6A163	Complementation	32296183
Intra	KRT86	O43790	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT86	O43790	KRT39	Homo sapiens	Q6A163	MAPPIT	32296183
Intra	KRT86	O43790	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KRT86	O43790	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT86	O43790	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT36	Homo sapiens	O76013-2	Validated Y2H	32296183
Intra	KRT86	O43790	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	KRT86	O43790	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT86	O43790	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT86	O43790	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT86	O43790	IL16	Homo sapiens	Q14005-2	Validated Y2H	32296183
Intra	KRT86	O43790	IL16	Homo sapiens	Q14005-2	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	KRT86	O43790	JOSD1	Homo sapiens	Q15040	Validated Y2H	32296183
Intra	KRT86	O43790	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	KRT86	O43790	KRT76	Homo sapiens	Q01546	Validated Y2H	32296183
Intra	KRT86	O43790	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT86	O43790	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT86	O43790	RESF1	Homo sapiens	Q9HCM1	Validated Y2H	32296183
Intra	KRT86	O43790	KRT16	Homo sapiens	P08779	Validated Y2H	32296183
Intra	KRT86	O43790	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT86	O43790	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	KRT86	O43790	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	KRT86	O43790	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	KRT86	O43790	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	KRT86	O43790	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	KRT86	O43790	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	KRT86	O43790	KRT14	Homo sapiens	P02533	Validated Y2H	32296183
Intra	KRT86	O43790	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	KRT86	O43790	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT86	O43790	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KRT86	O43790	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	KRT86	O43790	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	KRT86	O43790	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT19	Homo sapiens	P08727	Validated Y2H	32296183
Intra	KRT86	O43790	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT86	O43790	ZNF414	Homo sapiens	Q96IQ9	Validated Y2H	32296183
Intra	KRT86	O43790	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
Intra	KRT86	O43790	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	KRT86	O43790	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	KRT86	O43790	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	KRT86	O43790	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	KRT86	O43790	MAPKBP1	Homo sapiens	O60336	Validated Y2H	32296183
Intra	KRT86	O43790	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT86	O43790	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT86	O43790	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Black Piedra	Tinea Nodosa Trichomycosis Nodularis Chignon Disease
Keratosis	Actinic Keratosis Hyperkeratosis
Hypotrichosis 6	HYPT6 Lah1 Hypotrichosis, Localized, Autosomal Recessive Monilethrix-Like Hypotrichosis Hypotrichosis, Localized, Autosomal Recessive 1 Lah Htl Autosomal Recessive Localized Hypotrichosis Hypotrichosis Localized Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 1 Hypotrichosis, Type 6
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
Hypotrichosis
Alopecia
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Loose Anagen Hair Syndrome	Loose Anagen Syndrome LAHS
Diffuse Alopecia Areata	Diffuse Alopecia
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
T-Cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy	Winged Helix Deficiency Alymphoid Cystic Thymic Dysgenesis Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy Syndrome Pignata Guarino Syndrome TIDAND T-Cell Immunodeficiency, Congenital Alopecia And Nail Dystrophy Congenital Alopecia And Nail Dystrophy Associated With Severe Functional T-Cell Immunodeficiency Severe Combined Immunodeficiency Due To Foxn1 Deficiency Foxn1 Deficiency Nude/Scid Nude/Severe Combined Immunodeficiency Scid Due To Foxn1 Deficiency Severe T-Cell Immunodeficiency-Congenital Alopecia-Nail Dystrophy
Loeys-Dietz Syndrome 3	LDS3 Aneurysms-Osteoarthritis Syndrome Loeys-Dietz Syndrome With Osteoarthritis Aneurysm-Osteoarthritis Syndrome Lds1c Loeys-Dietz Syndrome, Type 3 Loeys-Dietz Syndrome, Type 1c, Formerly Lds1c, Formerly Loeys-Dietz Syndrome Type 1c Loeys-Dietz Syndrome Type 3 Aneurysm - Osteoarthritis Syndrome Loeys-Dietz Syndrome, Type 1c Aos Loeys-Dietz Syndrome 1c
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Agnathia-Otocephaly Complex	Otocephaly Holoprosencephaly-Agnathia Dysgnathia Complex Agnathia-Holoprosencephaly AGOTC Agnathia-Holoprosencephaly-Situs Inversus Syndrome Dysgnathia Complex Agnathia-Holoprosencephaly Cervical Auricle
White Piedra	Tinea Blanca Trichosporosis Nodosa
Microphthalmia, Syndromic 6	MCOPS6 Microphthalmia And Pituitary Anomalies Microphthalmia With Brain And Digit Anomalies Microphthalmia With Brain And Digit Developmental Anomalies Syndromic Microphthalmia Type 6 Syndromic Microphthalmia 6 Anophthalmia Clinical With Micrognathia Malformed Ears Digital Anomalies And Abnormal External Genitalia Bakrania-Ragge Syndrome Orofacial Cleft 11 Anophthalmia, Clinical, With Micrognathia, Malformed Ears, Digital Anomalies, And Abnormal External Genitalia Microphthalmia Syndromic 6 Microphthalmia, Syndromic, 6 Clinical Anophthalmia With Micrognathia, Malformed Ears, Digital Anomalies And Abnormal External Genitalia Microphthalmia Syndromic, Type 6
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation	Epidermolysis Bullosa Simplex With Mottled Pigmentation Ebsmp Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering Ebs-Mp EBS2F Ebs With Mottled Pigmentation Epidermolysis Bullosa Simplex-Mp Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Dermatopathia Pigmentosa Reticularis	DPR
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Sucrase-Isomaltase Deficiency, Congenital	Congenital Sucrase-Isomaltase Deficiency CSID Si Deficiency Congenital Sucrose Intolerance Disaccharide Intolerance Sucrase-Isomaltase Deficiency Disaccharide Intolerance I Congenital Sucrose-Isomaltose Malabsorption Sucrose-Isomaltose Malabsorption, Congenital Sucrose Intolerance, Congenital Congenital Sucrase-Isomaltose Malabsorption Congenital Sucrose-Isomaltase Malabsorption Disaccharide Intolerance, 1 Sucrose Intolerance Congenital Sucrose-Isomaltase Malabsorption, Congenital Disaccharidase Deficiency Invertase Deficiency Sucrase-Alpha-Dextrinase Deficiency Disaccharide Intolerance Type I Csid - [Congenital Sucrase-Isomaltase Deficiency] Sucrose Intolerance Of Newborn Sucrose Intolerance Sucrase Deficiency Disaccharide Malabsorption Intestinal Disaccharidase Deficiency
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07471	KRT86 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19346	Krt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT86	MGD	MGI:109362
Rattus norvegicus	KRT86	RGD	RGD:1303215
Macaca mulatta	KRT86	VGNC	VGNC:107243
Others	KRT86	NCBI