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JOSD1 - Josephin domain containing 1 Gene

Also Known as dJ508I15.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9929

About JOSD1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,685,543-38,701,403 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 27.2), gall bladder (RPKM 19.0) and 25 other tissues.

Summary

Predicted to enable thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

JOSD1 Products (3)

mRNA	Protein	Name
NM_001360235.2	NP_001347164.1	josephin-1
NM_001360236.2	NP_001347165.1	josephin-1
NM_014876.7	NP_055691.1	josephin-1

JOSD1 Protein Structure

Josephin

0
100
202 a.a.

Protein Preferred Names	Protein Names
josephin-1	josephin domain-containing 1

JOSD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JOSD1	Q15040	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	JOSD1	Q15040	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	JOSD1	Q15040	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	JOSD1	Q15040	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	JOSD1	Q15040	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	JOSD1	Q15040	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRTAP10-4	Homo sapiens	P60372	Validated Y2H	25416956
Intra	JOSD1	Q15040	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	JOSD1	Q15040	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	JOSD1	Q15040	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	JOSD1	Q15040	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	JOSD1	Q15040	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	JOSD1	Q15040	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	JOSD1	Q15040	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	JOSD1	Q15040	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	JOSD1	Q15040	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	JOSD1	Q15040	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	JOSD1	Q15040	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	JOSD1	Q15040	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	JOSD1	Q15040	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	JOSD1	Q15040	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	JOSD1	Q15040	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	JOSD1	Q15040	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	JOSD1	Q15040	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	JOSD1	Q15040	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	JOSD1	Q15040	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	JOSD1	Q15040	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	JOSD1	Q15040	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	JOSD1	Q15040	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	JOSD1	Q15040	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	JOSD1	Q15040	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	JOSD1	Q15040	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	JOSD1	Q15040	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	JOSD1	Q15040	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	JOSD1	Q15040	FBLN2	Homo sapiens	P98095	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	FBLN2	Homo sapiens	P98095	Y2H Array	32296183
Intra	JOSD1	Q15040	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	JOSD1	Q15040	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	JOSD1	Q15040	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183
Intra	JOSD1	Q15040	KRT86	Homo sapiens	O43790	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07043	JOSD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20431	Josd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26940	Josd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JOSD1	VGNC	VGNC:73920
Felis catus	JOSD1	VGNC	VGNC:84041
Bos taurus	JOSD1	VGNC	VGNC:30379
Rattus norvegicus	JOSD1	RGD	RGD:1305388
Canis familiaris	JOSD1	VGNC	VGNC:42192
Mus musculus	JOSD1	MGD	MGI:1921408
Others	JOSD1	NCBI