SHC3 - SHC adaptor protein 3 Gene

Also Known as RAI; NSHC; SHCC; N-Shc

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53358

About SHC3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:89,005,771-89,178,818 (from NCBI)

This gene has 2 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.7) and 2 other tissues.

Summary

Enables phosphotyrosine residue binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC3 Products (1)

mRNA Protein Name
NM_016848.6 NP_058544.3 SHC-transforming protein 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11877420 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC3 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (155 - 310)

SH2

SH2: SH2 domain (499 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 594 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 3

  • SH2 domain protein C3

SHC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SHC3 Q92529 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
SHC3 Q92529 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
SHC3 Q92529 PPP1R16B Homo sapiens Q96T49
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PPP1R16B Homo sapiens Q96T49
Validated Y2H
32296183
Intra
SHC3 Q92529 PPP1R16B Homo sapiens Q96T49
Y2H Array
32296183
Intra
SHC3 Q92529 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
SHC3 Q92529 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra
SHC3 Q92529 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
SHC3 Q92529 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra
SHC3 Q92529 DOK3 Homo sapiens Q7L591-3
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 DOK3 Homo sapiens Q7L591-3
Y2H Array
32296183
Intra
SHC3 Q92529 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
SHC3 Q92529 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 YPEL5 Homo sapiens P62699
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 YPEL5 Homo sapiens P62699
Y2H Array
32296183
Intra
SHC3 Q92529 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
SHC3 Q92529 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra
SHC3 Q92529 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
SHC3 Q92529 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
SHC3 Q92529 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
SHC3 Q92529 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
SHC3 Q92529 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
SHC3 Q92529 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Array
32296183
Intra
SHC3 Q92529 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra
SHC3 Q92529 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra
SHC3 Q92529 TSC1 Homo sapiens Q86WV8
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 TSC1 Homo sapiens Q86WV8
Y2H Array
32296183
Intra
SHC3 Q92529 KIT Homo sapiens P10721
FPS
24728074
Intra
SHC3 Q92529 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 TRIM35 Homo sapiens Q9UPQ4-2
Validated Y2H
32296183
Intra
SHC3 Q92529 TRIM35 Homo sapiens Q9UPQ4-2
Y2H Array
32296183
Intra
SHC3 Q92529 CDCA4 Homo sapiens Q9BXL8
Validated Y2H
32296183
Intra
SHC3 Q92529 CDCA4 Homo sapiens Q9BXL8
Y2H Array
32296183
Intra
SHC3 Q92529 CDCA4 Homo sapiens Q9BXL8
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 FTO Homo sapiens Q9C0B1-2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 FTO Homo sapiens Q9C0B1-2
Validated Y2H
32296183
Intra
SHC3 Q92529 FTO Homo sapiens Q9C0B1-2
Y2H Array
32296183
Intra
SHC3 Q92529 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra
SHC3 Q92529 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
SHC3 Q92529 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
Intra
SHC3 Q92529 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
SHC3 Q92529 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
SHC3 Q92529 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 SMYD3 Homo sapiens Q9H7B4
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 SMYD3 Homo sapiens Q9H7B4
Y2H Array
32296183
Intra
SHC3 Q92529 SMYD3 Homo sapiens Q9H7B4
Validated Y2H
32296183
Intra
SHC3 Q92529 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
SHC3 Q92529 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
SHC3 Q92529 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PSMD8 Homo sapiens P48556
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PSMD8 Homo sapiens P48556
Y2H Array
32296183
Intra
SHC3 Q92529 BMF Homo sapiens Q96LC9
Validated Y2H
32296183
Intra
SHC3 Q92529 BMF Homo sapiens Q96LC9
Y2H Array
32296183
Intra
SHC3 Q92529 BMF Homo sapiens Q96LC9
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra
SHC3 Q92529 CEACAM6 Homo sapiens P40199
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 CEACAM6 Homo sapiens P40199
Y2H Array
32296183
Intra
SHC3 Q92529 COPS6 Homo sapiens Q7L5N1
Y2H Array
32296183
Intra
SHC3 Q92529 COPS6 Homo sapiens Q7L5N1
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
SHC3 Q92529 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
SHC3 Q92529 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
SHC3 Q92529 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra
SHC3 Q92529 CT55 Homo sapiens Q8WUE5
Y2H Array
32296183
Intra
SHC3 Q92529 CT55 Homo sapiens Q8WUE5
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 PMF1 Homo sapiens Q6P1K2
Y2H Array
32296183
Intra
SHC3 Q92529 PMF1 Homo sapiens Q6P1K2
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 STX11 Homo sapiens O75558
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 STX11 Homo sapiens O75558
Y2H Array
32296183
Intra
SHC3 Q92529 ERBB3 Homo sapiens P21860
Protein Array
16273093
Intra
SHC3 Q92529 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
SHC3 Q92529 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 APP Homo sapiens P05067
Pull Down
11877420
Intra
SHC3 Q92529 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
SHC3 Q92529 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
SHC3 Q92529 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
SHC3 Q92529 KRT86 Homo sapiens O43790
Y2H Array
32296183
Intra
SHC3 Q92529 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinal Cord Ependymoma

  • Ependymal Neoplasm Of The Spinal Cord

  • Spinal Ependymoma

  • Ependymoma Of Spinal Cord
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12858 SHC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22323 Shc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SHC3 VGNC VGNC:46141
Mus musculus SHC3 MGD MGI:106179
Felis catus SHC3 VGNC VGNC:97626
Bos taurus SHC3 VGNC VGNC:34591
Rattus norvegicus SHC3 RGD RGD:69348
Others SHC3 NCBI