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OLIG3 - oligodendrocyte transcription factor 3 Gene

Also Known as Bhlhb7; bHLHe20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 167826

About OLIG3

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:137,492,199-137,494,394 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 15 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OLIG3 Products (1)

mRNA	Protein	Name
NM_175747.2	NP_786923.1	oligodendrocyte transcription factor 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OLIG3 Protein Structure

HLH

0
100
200
272 a.a.

Protein Preferred Names	Protein Names
oligodendrocyte transcription factor 3	class B basic helix-loop-helix protein 7

OLIG3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OLIG3	Q7RTU3	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	OLIG3	Q7RTU3	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	OLIG3	Q7RTU3	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	OLIG3	Q7RTU3	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	ATN1	Homo sapiens	Q86V38	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	OLIG3	Q7RTU3	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	OLIG3	Q7RTU3	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	OLIG3	Q7RTU3	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	OLIG3	Q7RTU3	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	25416956
Intra	OLIG3	Q7RTU3	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	OLIG3	Q7RTU3	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	OLIG3	Q7RTU3	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	OLIG3	Q7RTU3	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	OLIG3	Q7RTU3	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	PROP1	Homo sapiens	O75360	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	PROP1	Homo sapiens	O75360	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	OLIG3	Q7RTU3	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183
Intra	OLIG3	Q7RTU3	KRT86	Homo sapiens	O43790	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

OLIG3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86999	Olig3 Antibody (YA6692)	WB, ICC/IF, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09779	OLIG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OLIG3	MGD	MGI:2149955
Bos taurus	OLIG3	VGNC	VGNC:32426
Macaca mulatta	OLIG3	VGNC	VGNC:83439
Rattus norvegicus	OLIG3	RGD	RGD:1305997
Canis familiaris	OLIG3	VGNC	VGNC:44119
Felis catus	OLIG3	VGNC	VGNC:63966
Others	OLIG3	NCBI