CTDSP1 - CTD small phosphatase 1 Gene

Also Known as NIF3; SCP1; NLIIF; NLI-IF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58190

About CTDSP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,396,351-218,405,941 (from NCBI)

This gene has 15 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in placenta (RPKM 26.9), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a member of the small C-terminal domain Phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

CTDSP1 Products (12)

mRNA Protein Name
NM_001206878.2 NP_001193807.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3
NM_001400268.1 NP_001387197.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
NM_001400269.1 NP_001387198.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4
NM_001400270.1 NP_001387199.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 5
NM_001400271.1 NP_001387200.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 6
NM_001400272.1 NP_001387201.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 7
NM_001400273.1 NP_001387202.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 8
NM_001400274.1 NP_001387203.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 9
NM_001400275.1 NP_001387204.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10
NM_001400276.1 NP_001387205.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 11
NM_021198.3 NP_067021.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
NM_182642.3 NP_872580.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: Inferred from direct assay
12721286 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12721286 GOA
Biological Process GO Annotation Evidence References Source
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12721286 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12721286 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12721286 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSP1 Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (92 - 250)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

CTDSP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTDSP1 Q9GZU7 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
CTDSP1 Q9GZU7 SMAD1 Homo sapiens Q15797
Anti Tag CoIP
16882717
Intra
CTDSP1 Q9GZU7 FANCL Homo sapiens Q9NW38
Validated Y2H
32296183
Cross
CTDSP1 Q9GZU7 Ctdsp1 Mus musculus P58466
Anti Bait CoIP
14743429
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
33961781
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
27880917
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Pooling
16189514
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
28514442
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Prey Pooling
25416956
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Validated Y2H
25416956
Intra
CTDSP1 Q9GZU7 CDCA3 Homo sapiens Q99618
Y2H Array
25416956
Intra
CTDSP1 Q9GZU7 CSTF2T Homo sapiens Q9H0L4
Validated Y2H
32296183
Intra
CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Y2H Prey Pooling
25416956
Intra
CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Y2H Array
25416956
Intra
CTDSP1 Q9GZU7 MBP Homo sapiens P02686
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03291 CTDSP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CTDSP1 VGNC VGNC:39693
Felis catus CTDSP1 VGNC VGNC:61247
Rattus norvegicus CTDSP1 RGD RGD:1305629
Mus musculus CTDSP1 MGD MGI:2654470
Macaca mulatta CTDSP1 VGNC VGNC:71448
Bos taurus CTDSP1 VGNC VGNC:27790
Others CTDSP1 NCBI