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CDCA3 - cell division cycle associated 3 Gene

Also Known as GRCC8; TOME1; TOME-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83461

About CDCA3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,844,798-6,851,286 (from NCBI)

This gene has 12 transcripts (splice variants) and 176 orthologues. Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues.

Summary

Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]

CDCA3 Products (5)

mRNA	Protein	Name
NM_001297602.3	NP_001284531.1	cell division cycle-associated protein 3 isoform 2
NM_001297603.3	NP_001284532.1	cell division cycle-associated protein 3 isoform 3
NM_001297604.3	NP_001284533.1	cell division cycle-associated protein 3 isoform 4
NM_001331019.2	NP_001317948.1	cell division cycle-associated protein 3 isoform 5
NM_031299.7	NP_112589.1	cell division cycle-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in adherens junction	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cell division cycle-associated protein 3	gene-rich cluster protein C8

CDCA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	CDCA3	Q99618	CTDSPL	Homo sapiens	O15194-2	Y2H Array	32296183
Intra	CDCA3	Q99618	CTDSPL	Homo sapiens	O15194-2	Y2H Prey Pooling	32296183
Intra	CDCA3	Q99618	CTDSP2	Homo sapiens	O14595	Validated Y2H	25416956
Intra	CDCA3	Q99618	CTDSP2	Homo sapiens	O14595	Y2H Prey Pooling	32296183
Intra	CDCA3	Q99618	CTDSP2	Homo sapiens	O14595	Y2H Array	32296183
Intra	CDCA3	Q99618	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	CDCA3	Q99618	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CDCA3	Q99618	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CDCA3	Q99618	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	CDCA3	Q99618	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	CDCA3	Q99618	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	CDCA3	Q99618	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	CDCA3	Q99618	CTDSP1	Homo sapiens	Q9GZU7	Y2H Array	31515488
Intra	CDCA3	Q99618	CTDSP1	Homo sapiens	Q9GZU7	Validated Y2H	32296183
Intra	CDCA3	Q99618	CTDSP1	Homo sapiens	Q9GZU7	Anti Tag CoIP	33961781
Intra	CDCA3	Q99618	CTDSP1	Homo sapiens	Q9GZU7	Y2H Prey Pooling	32296183
Intra	CDCA3	Q99618	CTDSP1	Homo sapiens	Q9GZU7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CDCA3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P83431	CDCA3 Antibody (YA3176)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Night Blindness, Congenital Stationary, Type 1h	Congenital Stationary Night Blindness 1h CSNB1H Congenital Stationary Night Blindness Type 1h Night Blindness, Congenital Stationary, 1h
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS02312	CDCA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20874	Cdca3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27391	Cdca3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDCA3	MGD	MGI:1315198
Canis familiaris	CDCA3	VGNC	VGNC:39013
Felis catus	CDCA3	VGNC	VGNC:83523
Macaca mulatta	CDCA3	VGNC	VGNC:70711
Rattus norvegicus	CDCA3	RGD	RGD:1359093
Bos taurus	CDCA3	VGNC	VGNC:27084
Others	CDCA3	NCBI