CTDSP2 - CTD small phosphatase 2 Gene

Also Known as OS4; PSR2; SCP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10106

About CTDSP2

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,819,927-57,846,729 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in lung (RPKM 63.4), ovary (RPKM 53.0) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CTDSP2 Products (1)

mRNA Protein Name
NM_005730.4 NP_005721.3 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: Inferred from direct assay
12721286 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16724108 GOA
Biological Process GO Annotation Evidence References Source
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12721286 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSP2 Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (103 - 261)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

CTDSP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CTDSP2 O14595 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra
CTDSP2 O14595 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
CTDSP2 O14595 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
CTDSP2 O14595 N4BP3 Homo sapiens O15049
Y2H Array
32296183
Intra
CTDSP2 O14595 N4BP3 Homo sapiens O15049
Validated Y2H
32296183
Intra
CTDSP2 O14595 N4BP3 Homo sapiens O15049
Y2H Prey Pooling
32296183
Intra
CTDSP2 O14595 AR Homo sapiens P10275
Pull Down
16724108
Intra
CTDSP2 O14595 AR Homo sapiens P10275
Y2H
16724108
Intra
CTDSP2 O14595 AR Homo sapiens P10275
Anti Tag CoIP
16724108
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
28514442
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
27880917
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Y2H Prey Pooling
25416956
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Anti Tag CoIP
33961781
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Validated Y2H
32296183
Intra
CTDSP2 O14595 CDCA3 Homo sapiens Q99618
Y2H Array
25416956
Cross
CTDSP2 O14595 tax Human T-cell leukemia virus 1 P14079
MAPPIT
22458338
Cross
CTDSP2 O14595 tax Human T-cell leukemia virus 1 P14079
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myringitis Bullosa Hemorrhagica

  • Bullous Myringitis
Myasthenic Syndrome, Congenital, 16

  • Congenital Myasthenic Syndrome 16

  • CMS16

  • Myasthenic Syndrome, Congenital, Acetazolamide-Responsive

  • Congenital Myasthenic Syndrome Acetazolamide-Responsive

  • Congenital Myasthenic Syndrome Due To Mutation In Scn4a

  • Congenital Myasthenic Syndrome Scn4a-Related
Acute Tympanitis

  • Acute Myringitis
Obsessive-Compulsive Personality Disorder

  • Anankastic Personality Disorder

  • Obsessive-Compulsive Personality

  • Compulsive Personality Disorder

  • Ocpd

  • Obsessional Personality Disorder
Dermatosis Papulosa Nigra
Otosclerosis

  • Otospongiosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03292 CTDSP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CTDSP2 VGNC VGNC:71427
Canis familiaris CTDSP2 VGNC VGNC:39694
Bos taurus CTDSP2 VGNC VGNC:27791
Rattus norvegicus CTDSP2 RGD RGD:2319209
Mus musculus CTDSP2 MGD MGI:1098748
Felis catus CTDSP2 VGNC VGNC:61248
Others CTDSP2 NCBI