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Cat. No.: HY-113360

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Chenodeoxycholic acid 3-sulfate

Name: Chenodeoxycholic acid 3-sulfate
Brand: MedChemExpress
SKU: HY-113360
Availability: PreOrder

(Synonyms: CDCA-3-S)

Chenodeoxycholic acid 3-sulfate (CDCA-3-S) is a sulfated bile acid metabolite. Chenodeoxycholic acid 3-sulfate inhibits biliary organic anion excretion and induces bile flow, increased bile secretion, and increased biliary cholesterol secretion. Chenodeoxycholic acid 3-sulfate reduces hepatic bile acid uptake influx, binds to albumin, and is excreted into bile after hepatic uptake. Chenodeoxycholic acid 3-sulfate can be used in research on cholestasis.

For research use only. We do not sell to patients.

CAS No.: 59132-32-0
Formula: C₂₄H₄₀O₇S
Molecular Weight:472.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (308 KB)

Chenodeoxycholic acid 3-sulfate Chemical Structure

CAS No.: 59132-32-0

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Chenodeoxycholic acid 3-sulfate (CDC3S) binds strongly to albumin in equilibrium dialysis, with a binding rate of 84.7% at 0.5 μM and 89.1% at 50 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipid Metabolism

Chenodeoxycholic acid 3-sulfate (CDCA-3S) (5.0 μmol/min/kg; i.v. jugular vein infusion; single dose; 1 hour) has a choleretic effect in bile fistula male Sprague-Dawley rats, increasing the biliary output of bile acids and cholesterol without altering phospholipid output, and is excreted in bile as the intact sulfate conjugate and as taurine/glycine amide conjugates^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male; 200-230 g)^[4]
Dosage:

5.0 μmol/min/kg body wt
Administration:

i.v. infusion via jugular vein; single; 1-hr
Result:

Increased biliary bile acid secretion to a maximum of 99 nmol/min/g liver, corresponding to 3.98 μmol/min/kg body wt; basal biliary bile acid secretion was 36 nmol/min/g liver (1.44 μmol/min/kg body wt).
The apparent choleretic activity was 12.2 μl/μmol.
Increased biliary cholesterol output to a maximum of 1.9 nmol/min/g liver (76.0 nmol/min/kg body wt), from a preinfusion value of 1.5 nmol/min/g liver.
Biliary phospholipid output did not change during infusion.
In pooled bile, the measured product after solvolysis/hydrolysis was 6.9% at baseline, 37.5% at 20-40 min, 61.8% at 60-80 min, 15.6% at 100-120 min, and 10.3% at 180-200 min.
Underwent partial amidation: 30% of the infused bile acid was recovered as the taurine conjugate and 30% as the glycine conjugate in bile.
Negative-ion FAB-MS showed predominant ions at m/z 471 and 493 for unchanged sulfate and the sodium adduct, and ions at m/z 550 and 600 for the glycine and taurine conjugates, respectively.

Chemical Information

CAS No. 59132-32-0
Molecular Weight 472.64
Formula C₂₄H₄₀O₇S
SMILES

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Synonyms

CDCA-3-S
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (308 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics. Chemosphere. 2021 Jul;275:130049.

[2]. Yousef IM, et al. Effect of complete sulfation of bile acids on bile formation in rats. Hepatology. 1987 May;7(3):535-42.

[3]. Vakeesan N, et al. Bile Acid Analogs with Anti-Germination Activities for Prophylaxis of Clostridioides difficile Infection Alter Bile Acid Homeostasis in the Enterohepatic Cycle. Biomolecules. 2025 Dec 1;15(12):1672. [Content Brief]

[4]. Yamashita H, et al. Metabolism and effect of 7-oxo-lithocholic acid 3-sulfate on bile flow and biliary lipid secretion in rats. Hepatology (Baltimore, Md.). 1994 Sep;20(3):663-71.

[5]. Eng C, et al. Chenodeoxycholic acid-3-sulfate: metabolism and excretion in the rat and hamster and effects on hepatic transport systems. Biochemical pharmacology. 1983 Dec 1;32(23):3555-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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