KRT83 - keratin 83 Gene

Also Known as HB3; Hb-3; EKVP5; MNLIX; KRTHB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3889

About KRT83

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,314,301-52,321,398 (from NCBI)

This gene has 1 transcript (splice variant), 43 orthologues, 68 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The Other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]

KRT83 Products (1)

mRNA	Protein	Name
NM_002282.3	NP_002273.3	keratin, type II cuticular Hb3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT83 Protein Structure

Filament

0
100
200
300
400
493 a.a.

Protein Preferred Names	Protein Names
keratin, type II cuticular Hb3	K83

KRT83 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT83	P78385	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT83	P78385	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT83	P78385	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	KRT83	P78385	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	KRT83	P78385	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	KRT83	P78385	KRTAP13-3	Homo sapiens	Q3SY46	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT83	P78385	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT83	P78385	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	KRT83	P78385	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT83	P78385	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT83	P78385	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	KRT83	P78385	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT83	P78385	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT83	P78385	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	KRT83	P78385	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT83	P78385	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT83	P78385	NRF1	Homo sapiens	Q16656-4	Validated Y2H	32296183
Intra	KRT83	P78385	CEP57	Homo sapiens	Q86XR8-3	Validated Y2H	32296183
Intra	KRT83	P78385	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KRT83	P78385	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	KRT83	P78385	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT83	P78385	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	KRT83	P78385	GNE	Homo sapiens	Q9Y223-2	Validated Y2H	32296183
Intra	KRT83	P78385	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT83	P78385	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT83	P78385	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	PLEKHN1	Homo sapiens	Q494U1-3	Validated Y2H	32296183
Intra	KRT83	P78385	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KRT83	P78385	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	KRT83	P78385	POU4F2	Homo sapiens	Q12837	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	POU4F2	Homo sapiens	Q12837	Y2H Array	32296183
Intra	KRT83	P78385	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
Intra	KRT83	P78385	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	KRT83	P78385	ZDHHC1	Homo sapiens	Q8WTX9	Validated Y2H	32296183
Intra	KRT83	P78385	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT83	P78385	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT83	P78385	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT83	P78385	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	KRT83	P78385	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	KRT83	P78385	KRTAP3-3	Homo sapiens	Q9BYR6	MAPPIT	32296183
Intra	KRT83	P78385	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	KRT83	P78385	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRTAP3-3	Homo sapiens	Q9BYR6	Complementation	32296183
Intra	KRT83	P78385	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	KRT83	P78385	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	C11orf87	Homo sapiens	Q6NUJ2	Validated Y2H	32296183
Intra	KRT83	P78385	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT83	P78385	OTX1	Homo sapiens	P32242	Y2H Array	32296183
Intra	KRT83	P78385	OTX1	Homo sapiens	P32242	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	KRT83	P78385	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT83	P78385	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT83	P78385	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT83	P78385	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT83	P78385	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	KRT83	P78385	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Erythrokeratodermia Variabilis Et Progressiva 5	EKVP5 Erythrokeratodermia Variabilis
Erythrokeratodermia Variabilis Et Progressiva 1	Erythrokeratodermia Variabilis Erythrokeratodermia Variabilis Et Progressiva Greither Disease Ekv Ekvp PSEK Erythrokeratodermia Variabilis With Erythema Gyratum Repens Keratosis Palmoplantaris Transgrediens Et Progrediens Transgrediens Et Progrediens Palmoplantar Keratoderma EKVP1 Erythrokeratodermia, Progressive Symmetric Erythrokeratodermia Figurata, Congenital Familial, In Plaques Keratoderma Palmoplantaris Transgrediens Keratosis Extremitatum Hereditaria Progrediens Erythrokeratodermia Variabilis, Mendes Da Costa Type Progressive Symmetric Erythrokeratodermia Erythrokeratodermia Figurata Variabilis Greither'S Disease Ekv-P Erythrokeratodermia Variabilis Of Mendes Da Costa Progressive Symmetrical Erythrokeratoderma Of Gottron Progressive Diffuse Ppk Progressive Diffuse Palmoplantar Keratoderma Transgrediens Et Progrediens Ppk Darier-Gottron Disease Erythrokeratodermia Progressiva Symmetrica Progressive Symmetric Erythrokeratodermia, Gottron Type Congenital Familial Erythrokeratodermia Figurata In Plaques Erythrokeratodermia Progressive Symmetric Erythrokeratodermia Variabilis Mendes Da Costa Type
Hypotrichosis 6	HYPT6 Lah1 Hypotrichosis, Localized, Autosomal Recessive Monilethrix-Like Hypotrichosis Hypotrichosis, Localized, Autosomal Recessive 1 Lah Htl Autosomal Recessive Localized Hypotrichosis Hypotrichosis Localized Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 1 Hypotrichosis, Type 6
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
Ectodermal Dysplasia 4, Hair/Nail Type	Pure Hair And Nail Ectodermal Dysplasia ECTD4 Ectodermal Dysplasia, Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair/Nail Type Hned Hair-Nail Ectodermal Dysplasia Phned Ectodermal Dysplasia Pure Hair-Nail Type Ectodermal Dysplasia, 'Pure' Hair-Nail Type Dysplasia, Ectodermal, Type 4, Hair/Nail
Hypotrichosis
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate	Hay-Wells Syndrome Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome Aec Syndrome AEC Ankyloblepharon-Ectodermal Defects-Cleft Lip And Palate Syndrome Seres-Santamaria Arimany Muniz Syndrome Cleft Palate, Ankyloblepharon, Alveolar Synechiae, And Ectodermal Defects Ankyloblepharon Ectodermal Defects Cleft Lip/Palate Ankyloblepharon-Ectodermal Defect-Cleft Lip/Palate Rapp-Hodgkin Syndrome
Hair Disease	Hair Diseases Hair Anomaly Hair Disorder Hair Problems
Alopecia
Dermatopathia Pigmentosa Reticularis	DPR
Hypotrichosis 2	HYPT2 Hypotrichosis Simplex Of The Scalp 1 Htss1 Htss Hypotrichosis, Spanish Type Spanish Type Hypotrichosis Hypotrichosis Spanish Type Hypotrichosis, Type 2 Hypotrichosis Simplex Of Scalp
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Vohwinkel Syndrome	Mutilating Keratoderma Keratoderma Hereditarium Mutilans Khm VOWNKL Deafness, Congenital, With Keratopachydermia And Constrictions Of Fingers And Toes Mutilating Keratoderma Of Vohwinkel Mutilating Keratoderma Plus Deafness Ppk Mutilans And Deafness Congenital Deafness With Keratopachydermia And Constrictions Of Fingers And Toes Congenital Deafness With Keratopachydermia And Constrictions Fo Fingers And Toes Palmoplantar Keratoderma Mutilans Palmoplantar Keratoderma Mutilans Vohwinkel Ppk Mutilans Vohwinkel Mutilating Keratoderma Plus Hearing Loss Ppk Mutilans And Hearing Loss
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Ectodermal Dysplasia 10b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive	Hypohidrotic Ectodermal Dysplasia Hed Anhidrotic Ectodermal Dysplasia Ectodermal Dysplasia, Hypohidrotic Eda Christ-Siemens-Touraine Syndrome ECTD10B Ectodermal Dysplasia Anhidrotic Ectodermal Dysplasia, Anhidrotic Cst Syndrome Ectodermal Dysplasia Hypohidrotic Autosomal Recessive Dysplasia, Ectodermal, Type 10b, Hypohidrotic/Hair/Tooth, Autosomal Recessive Dysplasia, Ectodermal, Hypohidrotic Ectodermal Dysplasia 11b, Hypohidrotic/Hair/Tooth Type, Autosomal Recessive Ectodermal Dysplasia 3, Anhidrotic Ectodermal Dysplasia, Hypohidrotic, Autosomal Recessive
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07470	KRT83 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT83	RGD	RGD:1583565
Others	KRT83	NCBI