KRT2 - keratin 2 Gene

Also Known as K2e; KRTE; CK-2e; KRT2A; KRT2E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3849

About KRT2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,644,558-52,652,211 (from NCBI)

This gene has 2 transcripts (splice variants), 78 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward skin (RPKM 1015.4).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT2 Products (1)

mRNA	Protein	Name
NM_000423.3	NP_000414.2	keratin, type II cytoskeletal 2 epidermal

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables structural constituent of skin epidermis	IDA IDA: Inferred from direct assay	7543090	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in keratinization	IDA IDA: Inferred from direct assay	12598329	GOA
involved in keratinocyte activation	IDA IDA: Inferred from direct assay	12598329	GOA
involved in keratinocyte migration	IDA IDA: Inferred from direct assay	15737202	GOA
involved in keratinocyte proliferation	IDA IDA: Inferred from direct assay	12598329	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	7543090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	7543090	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	32179842	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT2 Protein Structure

Filament

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100
200
300
400
500
600
639 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 2 epidermal	cytokeratin-2e

KRT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Validated Y2H	25910212
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Y2H Array	25910212
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT40	Homo sapiens	Q6A162	SLC	25910212
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Y2H Array	25910212
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Validated Y2H	25910212
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	SLC	25910212
Intra	KRT2	P35908	KRT38	Homo sapiens	O76015	Y2H Array	31515488
Intra	KRT2	P35908	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT2	P35908	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT2	P35908	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT2	P35908	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT2	P35908	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT2	P35908	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT2	P35908	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT2	P35908	KRT13	Homo sapiens	P13646	Y2H Array	31515488
Intra	KRT2	P35908	KRT13	Homo sapiens	P13646	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT13	Homo sapiens	P13646	Validated Y2H	25910212
Intra	KRT2	P35908	KRT13	Homo sapiens	P13646	Y2H Array	25910212
Intra	KRT2	P35908	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT2	P35908	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT2	P35908	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	SLC	25910212
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	Validated Y2H	25910212
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	Y2H Array	25910212
Intra	KRT2	P35908	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Validated Y2H	25910212
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Y2H Array	25910212
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Validated Y2H	25416956
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Y2H Array	25416956
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Validated Y2H	25910212
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Y2H Bait-Prey Pool	25910212
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Y2H Array	25910212
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT2	P35908	KRT31	Homo sapiens	Q15323	SLC	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82926	Cytokeratin 2e Antibody (YA2671)	WB, IHC-P	Human
HY-P84280	Cytokeratin 2e Antibody (YA3977)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84280A	Cytokeratin 2e Antibody (YA3977)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Ichthyosis Bullosa Of Siemens	IBS Ichthyosis, Bullous Type Bullous Type Of Ichthyosis Ichthyosis Bullous Type
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Exfoliative Ichthyosis	Ichthyosis Exfoliativa Autosomal Recessive Exfoliative Ichthyosis
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Epidermolytic Acanthoma
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07443	KRT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22215	Krt2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KRT2	VGNC	VGNC:30721
Mus musculus	KRT2	MGD	MGI:96699
Rattus norvegicus	KRT2	RGD	RGD:1303297
Canis familiaris	KRT2	VGNC	VGNC:42520
Macaca mulatta	KRT2	VGNC	VGNC:74212
Others	KRT2	NCBI