GNG10 - G protein subunit gamma 10 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2790

About GNG10

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:111,661,605-111,670,226 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues and 11 paralogues. Ubiquitous expression in appendix (RPKM 57.2), adrenal (RPKM 51.1) and 25 other tissues.

Summary

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Apr 2022]

GNG10 Products (2)

mRNA Protein Name
NM_001017998.4 NP_001017998.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
NM_001198664.2 NP_001185593.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG10 Protein Structure

G-gamma

G-gamma: GGL domain (9 - 66)

  • 0
  • 68 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

  • guanine nucleotide binding protein (G protein), gamma 10

GNG10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG10 P50151 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
GNG10 P50151 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
GNG10 P50151 KRT38 Homo sapiens O76015
Y2H Array
31515488
Intra
GNG10 P50151 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra
GNG10 P50151 KRT38 Homo sapiens O76015
Y2H Array
25416956
Intra
GNG10 P50151 KRT38 Homo sapiens O76015
Y2H Array
29892012
Intra
GNG10 P50151 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
GNG10 P50151 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
GNG10 P50151 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
Intra
GNG10 P50151 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
GNG10 P50151 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Good Syndrome

  • Immunodeficiency With Thymoma

  • Thymoma-Immunodeficiency Syndrome

  • Thymoma With Hypogammaglobulinemia

  • Thymoma Immunodeficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05552 GNG10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GNG10 VGNC VGNC:56971
Canis familiaris GNG10 VGNC VGNC:97200
Rattus norvegicus GNG10 RGD RGD:621514
Mus musculus GNG10 MGD MGI:1336169
Others GNG10 NCBI