KRT6A - keratin 6A Gene

Also Known as K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3853

About KRT6A

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,487,176-52,493,257 (from NCBI)

This gene has 5 transcripts (splice variants), 139 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 2985.3).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against Bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

KRT6A Products (1)

mRNA	Protein	Name
NM_005554.4	NP_005545.1	keratin, type II cytoskeletal 6A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15731013	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	23006328	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IMP IMP: Inferred from mutant phenotype	23006328	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	23006328	GOA
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	23006328	GOA
involved in killing of cells of another organism	IDA IDA: Inferred from direct assay	23006328	GOA
involved in killing of cells of another organism	IMP IMP: Inferred from mutant phenotype	23006328	GOA
involved in negative regulation of entry of bacterium into host cell	IDA IDA: Inferred from direct assay	23006328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT6A Protein Structure

Filament

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 6A	cytokeratin 6A

KRT6A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT6A	P02538	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	KRT6A	P02538	KRT13	Homo sapiens	A1A4E9	Anti Tag CoIP	25416956
Intra	KRT6A	P02538	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	26871637
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Array	25910212
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Array	26871637
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	SLC	25910212
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Validated Y2H	26871637
Intra	KRT6A	P02538	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Array	31515488
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	SLC	25910212
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Array	25910212
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	KRT6A	P02538	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT6A	P02538	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25910212
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25910212
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	KRT6A	P02538	TFIP11	Homo sapiens	Q9UBB9	SLC	25910212
Intra	KRT6A	P02538	KIFC3	Homo sapiens	F5H3M2	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KIFC3	Homo sapiens	F5H3M2	Y2H Array	25910212
Intra	KRT6A	P02538	KIFC3	Homo sapiens	F5H3M2	SLC	25910212
Intra	KRT6A	P02538	KIFC3	Homo sapiens	F5H3M2	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT6A	P02538	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT6A	P02538	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT6A	P02538	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT6A	P02538	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Y2H Array	25910212
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT13	Homo sapiens	P13646	Y2H Array	31515488
Intra	KRT6A	P02538	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	KRT6A	P02538	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	KRT6A	P02538	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25910212
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	SLC	25910212
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25910212
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT6A	P02538	KRT18	Homo sapiens	P05783	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT18	Homo sapiens	P05783	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT18	Homo sapiens	P05783	Y2H Array	32296183
Intra	KRT6A	P02538	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT6A	P02538	NUP62	Homo sapiens	P37198	Validated Y2H	32296183
Intra	KRT6A	P02538	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	KRT6A	P02538	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	KRT6A	P02538	SGTA	Homo sapiens	O43765	Validated Y2H	25416956
Intra	KRT6A	P02538	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT6A	P02538	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT16	Homo sapiens	P08779	Validated Y2H	32296183
Intra	KRT6A	P02538	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	KRT6A	P02538	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25910212
Intra	KRT6A	P02538	GOLGA2	Homo sapiens	Q08379	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	GOLGA2	Homo sapiens	Q08379	Y2H Array	25910212
Intra	KRT6A	P02538	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Array	25910212
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Array	26871637
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	26871637
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	SLC	25910212
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Validated Y2H	26871637
Intra	KRT6A	P02538	KRT15	Homo sapiens	P19012	Y2H Pooling	16189514
Intra	KRT6A	P02538	CCDC85B	Homo sapiens	Q15834	Pull Down	16189514
Intra	KRT6A	P02538	CCDC85B	Homo sapiens	Q15834	Y2H Pooling	16189514
Intra	KRT6A	P02538	TRIM23	Homo sapiens	P36406	Validated Y2H	25910212
Intra	KRT6A	P02538	TRIM23	Homo sapiens	P36406	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	TRIM23	Homo sapiens	P36406	Y2H Array	25910212
Intra	KRT6A	P02538	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	KRT6A	P02538	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	KRT6A	P02538	HGS	Homo sapiens	O14964	Validated Y2H	26871637
Intra	KRT6A	P02538	HGS	Homo sapiens	O14964	Y2H Array	26871637
Intra	KRT6A	P02538	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	KRT6A	P02538	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	KRT6A	P02538	HGS	Homo sapiens	O14964	Y2H Prey Pooling	26871637
Intra	KRT6A	P02538	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT19	Homo sapiens	P08727	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT6A	P02538	GEM	Homo sapiens	P55040	Validated Y2H	32296183
Intra	KRT6A	P02538	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	KRT6A	P02538	NCALD	Homo sapiens	P61601	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	NCALD	Homo sapiens	P61601	Y2H Array	32296183
Intra	KRT6A	P02538	NCALD	Homo sapiens	P61601	Validated Y2H	32296183
Intra	KRT6A	P02538	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	KRT6A	P02538	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Validated Y2H	25910212
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	MAPPIT	25416956
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Y2H Array	25910212
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	Y2H Bait-Prey Pool	25910212
Intra	KRT6A	P02538	KRT31	Homo sapiens	Q15323	SLC	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT6A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81956	Cytokeratin 6A Antibody (YA1701)	WB, IHC-P, ICC/IF	Human
HY-P83353	Cytokeratin 6A Antibody (YA3098)	WB, IHC-P, ICC/IF	Human
HY-P83921	Cytokeratin 6A Antibody (YA3618)	WB, ICC/IF, FC, ELISA	Human
HY-P83921A	Cytokeratin 6A Antibody (YA3618)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P85826	Cytokeratin 6 Antibody (YA5518)	IHC-P, WB, ICC/IF, ELISA	Human
HY-P85990	Cytokeratin 6 Antibody (YA5682)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Pachyonychia Congenita 3	PC3 Pachyonychia Congenita, Type 3 Pc-3
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Cheilitis
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Focal Palmoplantar Keratoderma	Focal Ppk Focal Keratosis Palmoplantaris Focal Palmoplantar Hyperkeratosis
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Median Rhomboid Glossitis	Persistent Tuberculum Impar Glossitis Rhomboidea Mediana Superficial Midline Glossitis
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse	PPKNEFD Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Corneal Dystrophy
Epidermoid Cysts	Epidermoid Cyst Sebaceous Cyst Epidermal Inclusion Cyst Epidermal Cyst
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Palmoplantar Keratosis	Palmoplantar Keratoderma Keratosis Palmaris Et Plantaris Palmo-Plantar Keratodermas Keratoderma, Palmoplantar Keratoderma Palmoplantar Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Of Palms And Soles Palmoplantar Hyperkeratosis
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07458	KRT6A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	KRT6A	NCBI