EXOC5 - exocyst complex component 5 Gene

Also Known as SEC10; HSEC10; SEC10P; PRO1912; SEC10L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10640

About EXOC5

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:57,200,507-57,268,905 (from NCBI)

This gene has 11 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

EXOC5 Products (1)

mRNA	Protein	Name
NM_006544.4	NP_006535.1	exocyst complex component 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXOC5 Protein Structure

Sec10

0
200
400
600
708 a.a.

Protein Preferred Names	Protein Names
exocyst complex component 5	SEC10-like 1

EXOC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EXOC5	O00471	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	EXOC5	O00471	TTC23L	Homo sapiens	Q6PF05-3	Validated Y2H	25416956
Intra	EXOC5	O00471	TTC23L	Homo sapiens	Q6PF05-3	Y2H Array	25416956
Intra	EXOC5	O00471	RAB4B	Homo sapiens	P61018	Validated Y2H	32296183
Intra	EXOC5	O00471	EDRF1	Homo sapiens	Q3B7T1-5	Y2H Array	25416956
Intra	EXOC5	O00471	EDRF1	Homo sapiens	Q3B7T1-5	Validated Y2H	25416956
Intra	EXOC5	O00471	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	EXOC5	O00471	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	EXOC5	O00471	RAB14	Homo sapiens	P61106	Validated Y2H	25416956
Intra	EXOC5	O00471	RAB14	Homo sapiens	P61106	Validated Y2H	32296183
Intra	EXOC5	O00471	RAB14	Homo sapiens	P61106	Y2H Array	25416956
Intra	EXOC5	O00471	OAS1	Homo sapiens	P00973-2	Validated Y2H	32296183
Intra	EXOC5	O00471	EXOC6	Homo sapiens	Q8TAG9	TAP	27173435
Intra	EXOC5	O00471	EXOC6	Homo sapiens	Q8TAG9	Validated Y2H	32296183
Intra	EXOC5	O00471	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	EXOC5	O00471	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	EXOC5	O00471	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	EXOC5	O00471	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32814053
Intra	EXOC5	O00471	TSC1	Homo sapiens	Q86WV8	Y2H Array	32814053
Intra	EXOC5	O00471	TSC1	Homo sapiens	Q86WV8	Y2H Pooling	32814053
Intra	EXOC5	O00471	PTK6	Homo sapiens	Q13882	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	PTK6	Homo sapiens	Q13882	Validated Y2H	32296183
Intra	EXOC5	O00471	PTK6	Homo sapiens	Q13882	Y2H Array	25416956
Intra	EXOC5	O00471	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	EXOC5	O00471	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	EXOC5	O00471	THOC1	Homo sapiens	Q96FV9	Validated Y2H	32296183
Intra	EXOC5	O00471	EXOC6B	Homo sapiens	Q9Y2D4	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	EXOC6B	Homo sapiens	Q9Y2D4	Validated Y2H	32296183
Intra	EXOC5	O00471	EXOC6B	Homo sapiens	Q9Y2D4	Y2H Array	32296183
Intra	EXOC5	O00471	EXOC6B	Homo sapiens	Q9Y2D4	TAP	27173435
Intra	EXOC5	O00471	GAPDH	Homo sapiens	P04406	Y2H Array	32814053
Intra	EXOC5	O00471	GAPDH	Homo sapiens	P04406	Y2H Pooling	32814053
Intra	EXOC5	O00471	GAPDH	Homo sapiens	P04406	Validated Y2H	32814053
Intra	EXOC5	O00471	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32814053
Intra	EXOC5	O00471	STUB1	Homo sapiens	Q9UNE7	Y2H Array	32814053
Intra	EXOC5	O00471	STUB1	Homo sapiens	Q9UNE7	Y2H Pooling	32814053
Intra	EXOC5	O00471	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	EXOC5	O00471	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	EXOC5	O00471	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	EXOC5	O00471	OAS1	Homo sapiens	P00973	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	OAS1	Homo sapiens	P00973	Y2H Array	25416956
Intra	EXOC5	O00471	TNPO2	Homo sapiens	O14787	Validated Y2H	25416956
Intra	EXOC5	O00471	TNPO2	Homo sapiens	O14787	Y2H	21516116
Intra	EXOC5	O00471	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	EXOC5	O00471	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	EXOC5	O00471	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	EXOC5	O00471	BARD1	Homo sapiens	Q99728	Validated Y2H	25416956
Intra	EXOC5	O00471	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	EXOC5	O00471	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	EXOC5	O00471	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	EXOC5	O00471	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	EXOC5	O00471	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	EXOC5	O00471	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	EXOC5	O00471	MAGEA3	Homo sapiens	P43357	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	MAGEA3	Homo sapiens	P43357	Validated Y2H	32296183
Intra	EXOC5	O00471	MAGEA3	Homo sapiens	P43357	Y2H Array	32296183
Intra	EXOC5	O00471	BRMS1L	Homo sapiens	Q5PSV4	Y2H Array	25416956
Intra	EXOC5	O00471	BRMS1L	Homo sapiens	Q5PSV4	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	25416956
Intra	EXOC5	O00471	TXLNB	Homo sapiens	Q8N3L3	Y2H Array	31515488
Intra	EXOC5	O00471	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	EXOC5	O00471	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	EXOC5	O00471	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	EXOC5	O00471	RAB4A	Homo sapiens	P20338	Validated Y2H	25416956
Intra	EXOC5	O00471	RAB4A	Homo sapiens	P20338	Validated Y2H	32296183
Intra	EXOC5	O00471	RAB4A	Homo sapiens	P20338	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	SPACA9	Homo sapiens	Q96E40	Y2H Array	25416956
Intra	EXOC5	O00471	SPACA9	Homo sapiens	Q96E40	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	IFT57	Homo sapiens	Q9NWB7	Validated Y2H	32296183
Intra	EXOC5	O00471	IFT57	Homo sapiens	Q9NWB7	Y2H Array	32296183
Intra	EXOC5	O00471	IFT57	Homo sapiens	Q9NWB7	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	CRYAB	Homo sapiens	P02511	Y2H Pooling	32814053
Intra	EXOC5	O00471	CRYAB	Homo sapiens	P02511	Validated Y2H	32814053
Intra	EXOC5	O00471	CRYAB	Homo sapiens	P02511	Y2H Array	32814053
Intra	EXOC5	O00471	KXD1	Homo sapiens	Q9BQD3	Validated Y2H	25416956
Intra	EXOC5	O00471	KXD1	Homo sapiens	Q9BQD3	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	KXD1	Homo sapiens	Q9BQD3	Y2H Array	25416956
Intra	EXOC5	O00471	FRMD6	Homo sapiens	Q96NE9	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	USP2	Homo sapiens	O75604	Validated Y2H	32296183
Intra	EXOC5	O00471	TXNL4A	Homo sapiens	P83876	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Y2H Array	32296183
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Validated Y2H	32296183
Intra	EXOC5	O00471	DEUP1	Homo sapiens	Q05D60	Validated Y2H	25416956
Intra	EXOC5	O00471	HDDC3	Homo sapiens	Q8N4P3	Y2H Array	25416956
Intra	EXOC5	O00471	HDDC3	Homo sapiens	Q8N4P3	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	PYCARD	Homo sapiens	Q9ULZ3	Validated Y2H	25416956
Intra	EXOC5	O00471	PYCARD	Homo sapiens	Q9ULZ3	Y2H Array	25416956
Intra	EXOC5	O00471	PYCARD	Homo sapiens	Q9ULZ3	Y2H Prey Pooling	25416956
Intra	EXOC5	O00471	CRYBB1	Homo sapiens	P53674	Validated Y2H	32296183
Intra	EXOC5	O00471	FGA	Homo sapiens	P02671-2	Validated Y2H	32296183
Intra	EXOC5	O00471	FGA	Homo sapiens	P02671-2	Y2H Array	32296183
Intra	EXOC5	O00471	FGA	Homo sapiens	P02671-2	Y2H Prey Pooling	32296183
Intra	EXOC5	O00471	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	EXOC5	O00471	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	EXOC5	O00471	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053
Intra	EXOC5	O00471	BARD1	Homo sapiens	A0AVN2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04591	EXOC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EXOC5	VGNC	VGNC:72260
Mus musculus	EXOC5	MGD	MGI:2145645
Bos taurus	EXOC5	VGNC	VGNC:28649
Felis catus	EXOC5	VGNC	VGNC:62001
Rattus norvegicus	EXOC5	RGD	RGD:708408
Canis familiaris	EXOC5	VGNC	VGNC:40515
Others	EXOC5	NCBI