OAS1 - 2'-5'-oligoadenylate synthetase 1 Gene

Also Known as OIAS; IFI-4; OIASI; IMD100; E18/E16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4938

About OAS1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,906,962-112,933,219 (from NCBI)

This gene has 33 transcripts (splice variants), 167 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues.

Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular Antiviral response, and has been implicated in Other cellular processes like cell growth and Apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral Infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

OAS1 Products (15)

mRNA	Protein	Name
NM_001032409.3	NP_001027581.1	2'-5'-oligoadenylate synthase 1 isoform 3
NM_001320151.2	NP_001307080.1	2'-5'-oligoadenylate synthase 1 isoform 4
NM_001406020.1	NP_001392949.1	2'-5'-oligoadenylate synthase 1 isoform 5
NM_001406021.1	NP_001392950.1	2'-5'-oligoadenylate synthase 1 isoform 6
NM_001406022.1	NP_001392951.1	2'-5'-oligoadenylate synthase 1 isoform 7
NM_001406023.1	NP_001392952.1	2'-5'-oligoadenylate synthase 1 isoform 8
NM_001406024.1	NP_001392953.1	2'-5'-oligoadenylate synthase 1 isoform 9
NM_001406025.1	NP_001392954.1	2'-5'-oligoadenylate synthase 1 isoform 10
NM_001406026.1	NP_001392955.1	2'-5'-oligoadenylate synthase 1 isoform 11
NM_001406027.1	NP_001392956.1	2'-5'-oligoadenylate synthase 1 isoform 12
NM_001406029.1	NP_001392958.1	2'-5'-oligoadenylate synthase 1 isoform 13
NM_001406030.1	NP_001392959.1	2'-5'-oligoadenylate synthase 1 isoform 14
NM_001412228.1	NP_001399157.1	2'-5'-oligoadenylate synthase 1 isoform 15
NM_002534.4	NP_002525.2	2'-5'-oligoadenylate synthase 1 isoform 2
NM_016816.4	NP_058132.2	2'-5'-oligoadenylate synthase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	2434505	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	12799444	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15039538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	34581622	GOA
involved in antiviral innate immune response	IEP IEP: Inferred from expression pattern	25930096	GOA
involved in cellular response to interferon-alpha	IDA IDA: Inferred from direct assay	3753689	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	2434505	GOA
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	28146100	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	19923450	GOA
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23575436	GOA
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	23575436	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of IP-10 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	18931074	GOA
involved in positive regulation of cellular respiration	IDA IDA: Inferred from direct assay	31817188	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	11682059	GOA
involved in regulation of ribonuclease activity	IDA IDA: Inferred from direct assay	19923450	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	18931074	GOA
involved in surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	29455859	GOA
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28640813	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	21245038	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	3753689	GOA
located in cytosol	IDA IDA: Inferred from direct assay	31817188	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25205466	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	2434505	GOA
located in nucleus	IDA IDA: Inferred from direct assay	3753689	GOA
located in ribosome	IDA IDA: Inferred from direct assay	2434505	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OAS1 Protein Structure

NTP_transf_2

OAS1_C

0
100
200
300
400 a.a.

Protein Preferred Names	Protein Names
2'-5'-oligoadenylate synthase 1	(2-5')oligo(A) synthase 1

OAS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OAS1	P00973	ACTN1	Homo sapiens	P12814	Validated Y2H	25416956
Intra	OAS1	P00973	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	OAS1	P00973	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

OAS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811264	OAS1 Antibody	WB, IHC-P, ICC/IF	Human, Mouse

Related Diseases

Diseases	Alias
Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia	Pulmonary Alveolar Proteinosis With Hypogammaglobulinemia IMD100 Paphg
Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia	Oas1 Deficiency Oas1-Related Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Measles	Rubeola Morbilli Measles Nos Koplik Spots
West Nile Fever
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Pulmonary Alveolar Proteinosis
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Rubella	German Measles Three Day Measles Rubella Nos
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Mouth Disease	Mouth Diseases Mouth Disorders
Diabetes Mellitus	Diabetes
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-162465	BDW568	Agonist	99.4%	Unkown
HY-RS09727	OAS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OAS1	VGNC	VGNC:68606
Macaca mulatta	OAS1	VGNC	VGNC:75570
Rattus norvegicus	OAS1	RGD	RGD:621760
Canis familiaris	OAS1	VGNC	VGNC:44086
Others	OAS1	NCBI