2. Immunology/Inflammation
  3. STING IFNAR
  4. BDW568

BDW568 is a selective STINGA230 agonist with an EC50 of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research.

For research use only. We do not sell to patients.

BDW568

BDW568 Chemical Structure

CAS No. : 335401-44-0

Size Price Stock Quantity
1 mg In-stock
5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BDW568 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BDW568 is a selective STINGA230 agonist with an EC50 of 5.7 μM. BDW568 triggers the interferon signaling pathway and induces the expression of interferon-stimulated genes including MX1 and OAS1. BDW568 is applicable for cancer-related research[1][2][3].

In Vitro

BDW568 activates the STINGA230-mediated type I interferon signaling pathway in THP-1 cells, with an EC50 of 5.7 μM[2].
BDW568 (50 μM; 6 h) significantly upregulates the expression of MX1 and OAS1 in THP-1 cells[2].
BDW568 (serial dilution; 48 h) potently activates the STING pathway in THP-1 cells expressing STINGHAQ, with an EC50 of 5.7 μM[3].
BDW568 (50 μM; 6 h) significantly upregulates the interferon-stimulated genes MX1 and OAS1 in THP-1 cells expressing STINGHAQ[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BDW568 Related Antibodies

Real Time qPCR[2]

Cell Line: THP-1 cells (homozygous STINGHAQ genotype)
Concentration: 50 μM
Incubation Time: 6 h
Result: Induced elevated expression of ISGs MX1 and OAS1, with MX1 showing a relative mRNA expression level ~100-fold higher than mock-treated cells.

Real Time qPCR[3]

Cell Line: THP-1 cells (homozygous STINGHAQ)
Concentration: 50 μM
Incubation Time: 6 h
Result: Robustly elevated MX1 and OAS1 mRNA expression relative to vehicle-treated cells.
Molecular Weight

308.38

Formula

C12H12N4O2S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(CSC1=NN=C2N1C=NC3=C2C(C)=C(C)S3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.4%

SDS (252 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BDW568 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BDW568335401-44-0BDW 568BDW-568STINGIFNARStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptorprimary human macrophagesIFN-I signalingTHP-1 cellsIRF7OAS1CES1STINGG230MX1STINGA230PBMCsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BDW568
Cat. No.:
HY-162465
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.