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CES1

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By Targets:	Angiotensin-converting Enzyme (ACE) (2) Antibiotic (1) Cholinesterase (ChE) (1) HCV (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (2) Metabolic Disease (1) Neurological Disease (1)

8

Inhibitors & Agonists

1

Natural
Products

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Oseltamivir acid methyl ester	Antibiotic	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) ^[1].

WWL113	Others	Metabolic Disease
WWL113 is a selective and orally active Ces3 and *Ces1f* inhibitor, with IC₅₀ values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases) ^[1].

CES1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CES1 Human Pre-designed siRNA Set A contains three designed siRNAs for CES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CES1 Human Pre-designed siRNA Set A CES1 Human Pre-designed siRNA Set A

HCV-IN-39	HCV	Infection
HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC₅₀ values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons ^[1].

HCV-IN-40	HCV	Infection
HCV-IN-40 (Compound 18c) is a potent, orally active hepatitis C virus (HCV) nucleoside inhibitor with EC₅₀ values of 0.259, 0.434 and 0.069 μM against GT1a, GT1b and GT1b CES1 replicons ^[1].

Tanshinone IIA anhydride	Cholinesterase (ChE)	Cancer
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively ^[1].

Temocapril hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases ^[1] .

Temocapril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases ^[1] .

Species:	Human (1) Mouse (2)
Tag:	His (3)
Source:	HEK293 (2) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

	Carboxylesterase 1 Protein, Human (HEK293, His) rHuCarboxylesterase 1, His; CES1; Carboxylesterase 1; Cocaine Carboxylesterase; Serine Esterase 1; Triacylglycerol Hydrolase	Human	HEK293
	Carboxylesterase 1 Protein, Human (HEK293, His) is an approximately 60.0 kDa human carboxylesterase 1 protein with a His-flag. Human Carboxylesterase 1 is the key liver microsomal enzyme that takes part in detoxification and metabolism.

	Carboxylesterase 1C Protein, Mouse (P.pastoris, His) Carboxylesterase 1C; CES N; CES1c; Ee 1; Ee 4; Ee1; Es N; Es1; Es4; EsN; EST1C_MOUSE; Esterase 1; Liver carboxylesterase N; Lung surfactant convertase; PES-N; PESN	Mouse	P. pastoris
	The carboxylesterase 1C protein is essential for xenobiotic detoxification and ester/amide prodrug activation, as well as participating in extracellular metabolism. Its multifunctional effects include processing of pulmonary surfactant. Carboxylesterase 1C Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Carboxylesterase 1C protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Carboxylesterase 1C Protein, Mouse (P.pastoris, His) is 532 a.a., with molecular weight of ~60.6 kDa.

	CES3/CES1D Protein, Mouse (HEK293, His) rMuCarboxylesterase 1D/CES3, His; CES3; carboxylesterase 3; carboxylesterase 3 (brain); EC 3.1.1; EC 3.1.1.1; ES31FLJ21736; Esterase 31; Liver carboxylesterase 31 homolog	Mouse	HEK293
	CES3/CES1D Protein, a major lipase in white adipose tissue, plays a crucial role in xenobiotic and natural substrate metabolism. It hydrolyzes triacylglycerols and monoacylglycerols, showing a preference for the latter, with susceptibility increasing as the acyl chain length decreases. Additionally, CES3/CES1D catalyzes the synthesis of fatty acid ethyl esters and hydrolyzes retinyl esters. CES3/CES1D Protein, Mouse (HEK293, His) is the recombinant mouse-derived CES3/CES1D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CES3/CES1D Protein, Mouse (HEK293, His) is 543 a.a., with molecular weight of 58-70 kDa.

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