Tanshinone IIA anhydride
Based on 1 Customer Validation
Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a Ki value of 1.9 nM against hCE1 and a Ki value of 1.4 nM against hiCE. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies.
For research use only. We do not sell to patients.
- Purity: 97.03%
- CAS No.: 61077-78-9
- Formula: C19H18O4
- Molecular Weight:310.34
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 1.9 nM (Human carboxylesterase (CE)) and 1.4 nM (human intestinal CE)[1]
Tanshinone IIA anhydride (compound 4) potently and selectively inhibits recombinant human hCE1 (Ki = 1.9 nM) and hiCE (Ki = 1.4 nM)[1].
Tanshinone IIA anhydride (10 μM; 100 μM PMSF) forms a covalent adduct with the catalytic serine residue of recombinant human hCE1, as evidenced by mass shifts and blocked adduction in the presence of the serine-inactivating agent PMSF[1].
Tanshinone IIA anhydride (10 μM; 10 min) is cell-permeable and inhibits intracellular hCE1 activity in U373MG cells, reducing oseltamivir hydrolysis to 27% of control levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 61077-78-9
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Appearance Solid
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Molecular Weight 310.34
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Formula C19H18O4
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Color Light yellow to yellow
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SMILES
CC1(CCCC2=C1C=CC3=C2C(OC(C4=C3OC=C4C)=O)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tanshinone IIA anhydride Related Classifications
HY-N10686 Related Classifications
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