61077-78-9
Chemical Structure
Tanshinone IIA anhydride
- CAS No.: 61077-78-9
- Formula:C19H18O4
- Molecular Weight:310.34
IUPAC Name: 3-isopropyl-7-methyl-8-(4-methylpent-3-en-1-yl)naphthalene-1,2-dione
InChIKey: AZZOSPOHDDQAFO-UHFFFAOYSA-N
SMILES: CC1(CCCC2=C1C=CC3=C2C(OC(C4=C3OC=C4C)=O)=O)C
Biological Activity: Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a Ki value of 1.9 nM against hCE1 and a Ki value of 1.4 nM against hiCE. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tanshinone IIA anhydride | 97.03% | Tanshinone IIA anhydride, present in root extracts of Salvia miltiorrhiza, acts as an inhibitor of human carboxylesterase (CE). Tanshinone IIA anhydride has a Ki value of 1.9 nM against hCE1 and a Ki value of 1.4 nM against hiCE. Tanshinone IIA anhydride forms a stable covalent complex with serine Ser221 at the active site of hCE1, blocking the catalytic cycle of carboxylesterase, and the activity of the inactivated enzyme cannot recover spontaneously. Tanshinone IIA anhydride is applicable in metabolism-related studies. | ||||||||||||||||||||
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Keywords
