1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Temocapril hydrochloride

Temocapril hydrochloride 

Cat. No.: HY-B0384 Purity: 99.52%
Handling Instructions

Temocapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases.

For research use only. We do not sell to patients.

Temocapril hydrochloride Chemical Structure

Temocapril hydrochloride Chemical Structure

CAS No. : 110221-44-8

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10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 199 In-stock
Estimated Time of Arrival: December 31
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Description

Temocapril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases[1][2].

IC50 & Target

ACE[1]

In Vitro

Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[1]
Dosage: 30 mg/kg
Administration: Oral administration, daily, for 4 weeks
Result: Suppressed the blood pressure elevation induced by Ang I.
Molecular Weight

513.07

Formula

C₂₃H₂₉ClN₂O₅S₂

CAS No.

110221-44-8

SMILES

O=C(O)CN1C[[email protected]@H](C2=CC=CS2)SC[[email protected]](N[[email protected]](C(OCC)=O)CCC3=CC=CC=C3)C1=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (194.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9491 mL 9.7453 mL 19.4905 mL
5 mM 0.3898 mL 1.9491 mL 3.8981 mL
10 mM 0.1949 mL 0.9745 mL 1.9491 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TemocaprilAngiotensin-converting Enzyme (ACE)Temocaprilatangiotensin-convertingenzymeAngiotensin (I)hypertensionInhibitorinhibitorinhibit

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Product Name:
Temocapril hydrochloride
Cat. No.:
HY-B0384
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