1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Temocapril hydrochloride

Temocapril hydrochloride 

Cat. No.: HY-B0384 Purity: 99.52%
Handling Instructions

Temocapril Hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension.

For research use only. We do not sell to patients.

Temocapril hydrochloride Chemical Structure

Temocapril hydrochloride Chemical Structure

CAS No. : 110221-44-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 199 In-stock
Estimated Time of Arrival: December 31
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200 mg   Get quote  

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Description

Temocapril Hydrochloride is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. Target: ACE Temocapril hydrochloride is a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency [1]. Temocapril is regarded as an ACE inhibitor the disposition and efficacy of which are little affected in patients with impaired liver function [2].

Molecular Weight

513.07

Formula

C₂₃H₂₉ClN₂O₅S₂

CAS No.

110221-44-8

SMILES

O=C(O)CN1C[[email protected]@H](C2=CC=CS2)SC[[email protected]](N[[email protected]](C(OCC)=O)CCC3=CC=CC=C3)C1=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (194.91 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9491 mL 9.7453 mL 19.4905 mL
5 mM 0.3898 mL 1.9491 mL 3.8981 mL
10 mM 0.1949 mL 0.9745 mL 1.9491 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TemocaprilAngiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Product name:
Temocapril hydrochloride
Cat. No.:
HY-B0384
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