HCV-IN-39
HCV-IN-39 (Compound 18a) is a potent hepatitis C virus (HCV) nucleoside inhibitor with EC50 values of 0.644, 0.952 and 0.154 μM against GT1a, GT1b and GT1b CES1 replicons.
For research use only. We do not sell to patients.
- CAS No.: 2087916-31-0
- Formula: C21H26BrClN3O9P
- Molecular Weight:610.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.644 μM (GT1a), 0.952 μM (GT1b), 0.154 μM (GT1b CES1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
0.154 μM
Compound: 18a
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Antiviral activity against HCV genotype 1b Con1 over expressing CES1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 over expressing CES1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
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[PMID: 31740203] |
| Huh-7 | EC50 |
0.644 μM
Compound: 18a
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Antiviral activity against HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
|
[PMID: 31740203] |
| Huh-7 | EC50 |
0.952 μM
Compound: 18a
|
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
Antiviral activity against HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days by luciferase reporter gene assay
|
[PMID: 31740203] |
Chemical Information
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CAS No. 2087916-31-0
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Molecular Weight 610.78
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Formula C21H26BrClN3O9P
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SMILES
CCOC(C(C)(N[P@](OC[C@H]1O[C@H]([C@](Br)([C@@H]1O)Cl)N2C=CC(NC2=O)=O)(OC3=CC=CC=C3)=O)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HCV-IN-39 Related Classifications
HY-147763 Related Classifications
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