RAB4B - RAB4B, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53916

About RAB4B

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,778,247-40,796,942 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 18.9), spleen (RPKM 18.3) and 25 other tissues.

Summary

RAB proteins, such as RAB4B, are members of the Ras superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

RAB4B Products (1)

mRNA Protein Name
NM_016154.5 NP_057238.3 ras-related protein Rab-4B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
20534812 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in D-glucose import IMP
IMP: Inferred from mutant phenotype
19590752 GOA
involved in early endosome to Golgi transport IDA
IDA: Inferred from direct assay
36282215 GOA
involved in endosomal vesicle fusion IDA
IDA: Inferred from direct assay
20534812 GOA
Cellular Component GO Annotation Evidence References Source
is active in early endosome membrane IDA
IDA: Inferred from direct assay
20534812 GOA
located in insulin-responsive compartment IDA
IDA: Inferred from direct assay
19590752 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19590752 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
19590752 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB4B Protein Structure

Ras

Ras: Ras family (10 - 170)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-4B

  • ras-related GTP-binding protein 4b

RAB4B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAB4B P61018 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
RAB4B P61018 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
RAB4B P61018 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
RAB4B P61018 RABEP1 Homo sapiens Q15276
Validated Y2H
32296183
Intra
RAB4B P61018 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
RAB4B P61018 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
RAB4B P61018 GARIN6 Homo sapiens Q8NEG0
Y2H Prey Pooling
32296183
Intra
RAB4B P61018 GARIN6 Homo sapiens Q8NEG0
Validated Y2H
32296183
Intra
RAB4B P61018 GARIN6 Homo sapiens Q8NEG0
Y2H Array
32296183
Intra
RAB4B P61018 EXOC5 Homo sapiens O00471
Y2H Array
25416956
Intra
RAB4B P61018 EXOC5 Homo sapiens O00471
Y2H Array
32296183
Intra
RAB4B P61018 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
25416956
Intra
RAB4B P61018 EXOC5 Homo sapiens O00471
Validated Y2H
25416956
Intra
RAB4B P61018 EXOC5 Homo sapiens O00471
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11570 RAB4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB4B MGD MGI:105071
Canis familiaris RAB4B VGNC VGNC:53756
Rattus norvegicus RAB4B RGD RGD:620931
Others RAB4B NCBI