RAB14 - RAB14, member RAS oncogene family Gene

Also Known as FBP; RAB-14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51552

About RAB14

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,178,133-121,201,869 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues, 68 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 33.7), lung (RPKM 31.9) and 25 other tissues.

Summary

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

RAB14 Products (1)

mRNA	Protein	Name
NM_016322.4	NP_057406.2	ras-related protein Rab-14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	16034420	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16034420	GOA
enables myosin V binding	IPI IPI: Inferred from physical interaction	24006491	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16034420	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to Golgi transport	IDA IDA: Inferred from direct assay	36282215	GOA
involved in endocytic recycling	IDA IDA: Inferred from direct assay	22595670	GOA
involved in endosomal vesicle fusion	IDA IDA: Inferred from direct assay	20534812	GOA
involved in regulation of protein localization	IDA IDA: Inferred from direct assay	22595670	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
is active in early endosome membrane	IDA IDA: Inferred from direct assay	20534812	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	21255211	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	22595670	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB14 Protein Structure

Ras

0
100
200
215 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-14	F protein-binding protein 1

RAB14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB14	P61106	OCRL	Homo sapiens	Q01968	Y2H	16902405
Intra	RAB14	P61106	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Prey Pooling	32296183
Intra	RAB14	P61106	SH3BP5L	Homo sapiens	Q7L8J4	Validated Y2H	32296183
Intra	RAB14	P61106	SH3BP5L	Homo sapiens	Q7L8J4	Y2H Array	32296183
Intra	RAB14	P61106	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
Intra	RAB14	P61106	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	25416956
Intra	RAB14	P61106	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183
Intra	RAB14	P61106	EXOC5	Homo sapiens	O00471	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gapo Syndrome	GAPOS Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11523	RAB14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RAB14	VGNC	VGNC:97581
Bos taurus	RAB14	VGNC	VGNC:33622
Canis familiaris	RAB14	VGNC	VGNC:45254
Mus musculus	RAB14	MGD	MGI:1915615
Rattus norvegicus	RAB14	RGD	RGD:620881
Others	RAB14	NCBI