HDDC3 - HD domain containing 3 Gene

Also Known as MESH1; (ppGpp)ase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374659

About HDDC3

This gene has 10 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in fat (RPKM 9.9), kidney (RPKM 7.9) and 25 other tissues.

Summary

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]

HDDC3 Products (2)

mRNA Protein Name
NM_001286451.2 NP_001273380.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1
NM_198527.4 NP_940929.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDDC3 Protein Structure

HD_4

HD_4: HD domain (11 - 139)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

  • HD domain-containing protein 3

HDDC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDDC3 Q8N4P3 GOLGA8F Homo sapiens Q08AF8
Validated Y2H
25416956
Intra
HDDC3 Q8N4P3 GOLGA8F Homo sapiens Q08AF8
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 GOLGA8DP Homo sapiens Q0D2H9
Validated Y2H
25416956
Intra
HDDC3 Q8N4P3 GOLGA8DP Homo sapiens Q0D2H9
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 GOLGA8DP Homo sapiens Q0D2H9
Y2H Prey Pooling
25416956
Intra
HDDC3 Q8N4P3 CEP57L1 Homo sapiens Q8IYX8-2
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
HDDC3 Q8N4P3 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 TPM3 Homo sapiens Q5VU62
Y2H Prey Pooling
25416956
Intra
HDDC3 Q8N4P3 CCDC172 Homo sapiens P0C7W6
Y2H Array
31515488
Intra
HDDC3 Q8N4P3 CCDC172 Homo sapiens P0C7W6
Validated Y2H
25416956
Intra
HDDC3 Q8N4P3 TNIP1 Homo sapiens Q15025
Anti Tag CoIP
33961781
Intra
HDDC3 Q8N4P3 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
HDDC3 Q8N4P3 NMI Homo sapiens Q13287
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 GKAP1 Homo sapiens Q5VSY0
Y2H Array
25416956
Intra
HDDC3 Q8N4P3 GKAP1 Homo sapiens Q5VSY0
Validated Y2H
25416956
Intra
HDDC3 Q8N4P3 EXOC5 Homo sapiens O00471
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06093 HDDC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22548 Hddc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29068 Hddc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HDDC3 VGNC VGNC:108304
Canis familiaris HDDC3 VGNC VGNC:41626
Felis catus HDDC3 VGNC VGNC:62772
Rattus norvegicus HDDC3 RGD RGD:1311839
Mus musculus HDDC3 MGD MGI:1915945
Bos taurus HDDC3 VGNC VGNC:29786
Others HDDC3 NCBI