GKAP1 - G kinase anchoring protein 1 Gene

Also Known as FKSG21; GKAP42

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80318

About GKAP1

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,739,425-83,817,769 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Biased expression in testis (RPKM 88.6) and ovary (RPKM 4.2).

Summary

This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GKAP1 Products (2)

mRNA Protein Name
NM_001135953.2 NP_001129425.1 G kinase-anchoring protein 1 isoform b
NM_025211.4 NP_079487.2 G kinase-anchoring protein 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G kinase-anchoring protein 1

  • cGMP-dependent protein kinase anchoring protein 42kDa

GKAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GKAP1 Q5VSY0 DYR Homo sapiens B0YJ76
Y2H Array
25416956
Intra
GKAP1 Q5VSY0 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra
GKAP1 Q5VSY0 FAM124B Homo sapiens Q9H5Z6-2
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 PHOSPHO2 Homo sapiens Q8TCD6
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 ZCCHC10 Homo sapiens Q8TBK6
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 L3MBTL2 Homo sapiens Q969R5
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 MMTAG2 Homo sapiens Q9BU76
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 HDDC3 Homo sapiens Q8N4P3
Y2H Prey Pooling
25416956
Intra
GKAP1 Q5VSY0 GKAP1 Homo sapiens Q5VSY0
Y2H Array
32296183
Intra
GKAP1 Q5VSY0 GCD7 Saccharomyces cerevisiae P32502
Y2H Array
27107014
Intra
GKAP1 Q5VSY0 GCD7 Saccharomyces cerevisiae P32502
Y2H Pooling
27107014
Intra
GKAP1 Q5VSY0 GKAP1 Homo sapiens Q5VSY0
Validated Y2H
32296183
Intra
GKAP1 Q5VSY0 GKAP1 Homo sapiens Q5VSY0
Y2H Prey Pooling
32296183
Intra
GKAP1 Q5VSY0 GKAP1 Homo sapiens Q5VSY0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05460 GKAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GKAP1 VGNC VGNC:29387
Felis catus GKAP1 VGNC VGNC:62569
Mus musculus GKAP1 MGD MGI:1891694
Canis familiaris GKAP1 VGNC VGNC:41245
Rattus norvegicus GKAP1 RGD RGD:1306955
Others GKAP1 NCBI