DTX3 - deltex E3 ubiquitin ligase 3 Gene

Also Known as RNF154; deltex3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 196403

About DTX3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,604,824-57,609,802 (from NCBI)

This gene has 9 transcripts (splice variants), 183 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 21.6), endometrium (RPKM 16.7) and 24 other tissues.

Summary

DTX3 functions as an E3 ubiquitin Ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3 Products (3)

mRNA	Protein	Name
NM_001286245.2	NP_001273174.1	probable E3 ubiquitin-protein ligase DTX3 isoform b
NM_001286246.2	NP_001273175.1	probable E3 ubiquitin-protein ligase DTX3 isoform a
NM_178502.4	NP_848597.1	probable E3 ubiquitin-protein ligase DTX3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTX3 Protein Structure

zf-RING_2

0
100
200
300
347 a.a.

Protein Preferred Names	Protein Names
probable E3 ubiquitin-protein ligase DTX3	RING finger protein 154

DTX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DTX3	Q8N9I9	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	FYN	Homo sapiens	P06241-3	MAPPIT	32296183
Intra	DTX3	Q8N9I9	UBASH3B	Homo sapiens	Q8TF42	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	PARP11	Homo sapiens	Q9NR21-1	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	UBE2L6	Homo sapiens	O14933	Y2H Array	19549727
Intra	DTX3	Q8N9I9	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	UBE2K	Homo sapiens	P61086	Validated Y2H	25416956
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	DTX3	Q8N9I9	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	DTX3	Q8N9I9	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	DTX3	Q8N9I9	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	DTX3	Q8N9I9	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cutaneous Diphtheria	Diphtheria Wound Infection
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04040	DTX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04041	DTX3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19429	Dtx3l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25920	Dtx3l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DTX3	VGNC	VGNC:28238
Mus musculus	DTX3	MGD	MGI:2135752
Rattus norvegicus	DTX3	RGD	RGD:1566181
Canis familiaris	DTX3	VGNC	VGNC:40117
Macaca mulatta	DTX3	VGNC	VGNC:71896
Felis catus	DTX3	VGNC	VGNC:61650
Others	DTX3	NCBI