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CCDC88B - coiled-coil domain containing 88B Gene

Also Known as BRLZ; HKRP3; gipie; CCDC88

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283234

About CCDC88B

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,340,204-64,357,534 (from NCBI)

This gene has 10 transcripts (splice variants), 181 orthologues and 5 paralogues. Biased expression in bone marrow (RPKM 19.8), spleen (RPKM 16.5) and 13 other tissues.

Summary

This gene encodes a member of the hook-related protein family. Members of this family are characterized by an N-terminal potential microtubule binding domain, a central coiled-coiled and a C-terminal Hook-related domain. The encoded protein may be involved in linking organelles to microtubules. [provided by RefSeq, Oct 2009]

CCDC88B Products (1)

mRNA	Protein	Name
NM_032251.6	NP_115627.6	coiled-coil domain-containing protein 88B precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC88B Protein Structure

HOOK

0
300
600
900
1200
1476 a.a.

Protein Preferred Names	Protein Names
coiled-coil domain-containing protein 88B	78 kDa glucose-regulated protein [GRP78]-interacting protein induced by ER stress

CCDC88B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCDC88B	A6NC98	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TSGA10IP	Homo sapiens	Q3SY00	Y2H Prey Pooling	32296183
Intra	CCDC88B	A6NC98	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TSHZ2	Homo sapiens	Q9NRE2	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	DTNB	Homo sapiens	O60941-5	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	ZC2HC1C	Homo sapiens	Q53FD0-2	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	SH3KBP1	Homo sapiens	Q96B97	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	HOXB5	Homo sapiens	P09067	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	CWF19L2	Homo sapiens	Q2TBE0	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	CCDC88B	A6NC98	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	USP2	Homo sapiens	O75604	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	GEM	Homo sapiens	P55040	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TSGA10	Homo sapiens	Q9BZW7	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	DEF6	Homo sapiens	Q9H4E7	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	CDK18	Homo sapiens	Q07002	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	RBM7	Homo sapiens	Q9Y580	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	JAKMIP2	Homo sapiens	Q96AA8	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	LMNB1	Homo sapiens	P20700	Validated Y2H	32296183
Intra	CCDC88B	A6NC98	HCK	Homo sapiens	P08631-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02062	CCDC88B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28543	Rps6ka4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CCDC88B	VGNC	VGNC:38868
Rattus norvegicus	CCDC88B	RGD	RGD:1311475
Macaca mulatta	CCDC88B	VGNC	VGNC:100902
Felis catus	CCDC88B	VGNC	VGNC:60523
Bos taurus	CCDC88B	VGNC	VGNC:26928
Mus musculus	CCDC88B	MGD	MGI:1925567
Others	CCDC88B	NCBI