IRAK1 - interleukin 1 receptor associated kinase 1 Gene

Also Known as IRAK; pelle

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3654

About IRAK1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,010,507-154,019,902 (from NCBI)

This gene has 14 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues.

Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

IRAK1 Products (7)

mRNA	Protein	Name
NM_001025243.2	NP_001020414.1	interleukin-1 receptor-associated kinase 1 isoform 3
NM_001410701.1	NP_001397630.1	interleukin-1 receptor-associated kinase 1 isoform 4
NM_001569.4	NP_001560.2	interleukin-1 receptor-associated kinase 1 isoform 1
XM_047442098.1	XP_047298054.1	interleukin-1 receptor-associated kinase 1 isoform X3
XM_005274668.5	XP_005274725.1	interleukin-1 receptor-associated kinase 1 isoform X1
NM_001025242.2	NP_001020413.1	interleukin-1 receptor-associated kinase 1 isoform 2
XM_047442097.1	XP_047298053.1	interleukin-1 receptor-associated kinase 1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11397809	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	12054681	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10854325	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10383454	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	12054681	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	33238146	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	11960013	GOA
NOT enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11397809	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11397809	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25515214	GOA
NOT involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	11397809	GOA
involved in interleukin-1-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in interleukin-33-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	31435003	GOA
involved in lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	10383454	GOA
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22158417	GOA
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	25515214	GOA
involved in positive regulation of type I interferon production	IMP IMP: Inferred from mutant phenotype	23633945	GOA
NOT involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11397809	GOA
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	12054681	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10383454	GOA
involved in regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	10383454	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23633945	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cell surface	IDA IDA: Inferred from direct assay	22851693	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10854325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRAK1 Protein Structure

Death

Pkinase

0
200
400
600
712 a.a.

Protein Preferred Names	Protein Names
interleukin-1 receptor-associated kinase 1	Pelle homolog

IRAK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRAK1	P51617	TRAF6	Homo sapiens	Q9Y4K3	CoIP	11518704
Intra	IRAK1	P51617	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	26752465
Intra	IRAK1	P51617	MYD88	Homo sapiens	Q99836	Anti Bait CoIP	26752465
Intra	IRAK1	P51617	MYD88	Homo sapiens	Q99836	Anti Tag CoIP	17567694
Intra	IRAK1	P51617	PELI2	Homo sapiens	Q9HAT8	Pull Down	19081057
Intra	IRAK1	P51617	PELI3	Homo sapiens	Q8N2H9-2	Pull Down	19081057
Cross	IRAK1	P51617	Zc3h12a	Mus musculus	Q5D1E7	Protein Kinase Assay	22037600
Cross	IRAK1	P51617	Zc3h12a	Mus musculus	Q5D1E7	Anti Tag CoIP	22037600
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	Anti Bait CoIP	21743479
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	Pull Down	21743479
Intra	IRAK1	P51617	PIN1	Homo sapiens	Q13526	NMR	21743479
Intra	IRAK1	P51617	IRF4	Homo sapiens	Q15306	Anti Tag CoIP	21903422
Intra	IRAK1	P51617	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

IRAK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80420	IRAK-1 Antibody (YA335)	WB, IHC-P	Human, Mouse
HY-P82709	IRAK-1 Antibody (YA2454)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Fleck Retina, Familial Benign	FRFB Familial Benign Flecked Retina Familial Benign Fleck Retina
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type	Mecp2 Duplication Syndrome Lubs X-Linked Mental Retardation Syndrome MRXSL Trisomy Xq28 Mental Retardation, X-Linked, With Recurrent Respiratory Infections Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type Mental Retardation, X-Linked, Lubs Type Xlmr Syndrome, Lubs Type
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Syndromic X-Linked Intellectual Disability Lubs Type	Lubs X-Linked Mental Retardation Syndrome Mecp2 Duplication Syndrome Mental Retardation, X-Linked, Syndromic, Lubs Type Mental Retardation, X-Linked, With Recurrent Respiratory Infections Mrxsl X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome Mental Retardation, X-Linked Syndromic, Lubs Type
Gene Duplication Disease	Gene Duplication Syndrome
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Pediatric Systemic Lupus Erythematosus	Sle, Pediatric Onset
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Phototoxic Dermatitis	Dermatitis, Phototoxic Photosensitisation Reaction Photosensitive Dermatitis Photosensitiveness
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0380	Trimebutine	Inhibitor	99.42%	Yes
HY-B0380A	Trimebutine maleate	Inhibitor	99.66%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160487	KME-2780	Inhibitor	98.94%	Phase 2
HY-153110	Larotinib	Inhibitor	99.50%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0039	Ginsenoside Rb1	Inhibitor	99.75%	Unkown
HY-147141	HS-276	Inhibitor	98.93%	Unkown
HY-103017A	JH-X-119-01	Inhibitor	99.65%	Unkown
HY-153188	JNJ-1013	Degrader	99.97%	Unkown
HY-111101	AZ1495	Inhibitor	98.07%	Unkown
HY-103017	JH-X-119-01 hydrochloride	Inhibitor	99.14%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-134911	HS-243	Inhibitor	99.95%	Unkown
HY-159953	IRAK1/4/pan-FLT3 Kinase-IN-1	Inhibitor	99.25%	Unkown
HY-153224	GLPG2534	Inhibitor	98.73%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-N0039R	Ginsenoside Rb1 (Standard)	Inhibitor	99.26%	Unkown
HY-177515	IRAK4 modulator-2	Inhibitor	99.86%	Unkown
HY-179095	UR241-2	Inhibitor	99.68%	Unkown
HY-159953A	IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride	Inhibitor	98.46%	Unkown
HY-147141A	HS-276 hydrochloride	Inhibitor	/	Unkown
HY-181712	IRAK1-IN-2	Inhibitor	/	Unkown
HY-162641	AF-45	Inhibitor	/	Unkown
HY-B0380S2	Trimebutine-d3 hydrochloride	Inhibitor	/	Unkown
HY-125142	AP-24567	Inhibitor	/	Unkown
HY-147141B	HS-276 formic	Inhibitor	/	Unkown
HY-B0380S1	Trimebutine-d5 fumarate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRAK1	MGD	MGI:107420
Canis familiaris	IRAK1	VGNC	VGNC:42087
Rattus norvegicus	IRAK1	RGD	RGD:1563841
Bos taurus	IRAK1	VGNC	VGNC:30264
Macaca mulatta	IRAK1	VGNC	VGNC:73757
Felis catus	IRAK1	VGNC	VGNC:67819
Others	IRAK1	NCBI