IRAK1 - interleukin 1 receptor associated kinase 1 Gene

Homo sapiens

Also known as IRAK; pelle

Gene ID: 3654 | Gene type: protein coding

About IRAK1

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:154,010,507-154,019,902 (from NCBI)

This gene has 14 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues.

Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

IRAK1 Products(7)

mRNA	Protein	Name
NM_001025243.2	NP_001020414.1	interleukin-1 receptor-associated kinase 1 isoform 3
NM_001410701.1	NP_001397630.1	interleukin-1 receptor-associated kinase 1 isoform 4
NM_001569.4	NP_001560.2	interleukin-1 receptor-associated kinase 1 isoform 1
XM_047442098.1	XP_047298054.1	interleukin-1 receptor-associated kinase 1 isoform X3
XM_005274668.5	XP_005274725.1	interleukin-1 receptor-associated kinase 1 isoform X1
NM_001025242.2	NP_001020413.1	interleukin-1 receptor-associated kinase 1 isoform 2
XM_047442097.1	XP_047298053.1	interleukin-1 receptor-associated kinase 1 isoform X2

IRAK1 Protein Structure

Death

Pkinase

0
200
400
600
712 a.a.

Protein Preferred Names

Protein Names

interleukin-1 receptor-associated kinase 1

Pelle homolog

Related Diseases

Diseases

Alias

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Fleck Retina, Familial Benign

FRFB	Familial Benign Flecked Retina
Familial Benign Fleck Retina

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type

Mecp2 Duplication Syndrome	Lubs X-Linked Mental Retardation Syndrome
MRXSL	Trisomy Xq28
Mental Retardation, X-Linked, With Recurrent Respiratory Infections	Intellectual Developmental Disorder, X-Linked Syndromic, Lubs Type
Mental Retardation, X-Linked, Lubs Type	Xlmr Syndrome, Lubs Type

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Syndromic X-Linked Intellectual Disability Lubs Type

Lubs X-Linked Mental Retardation Syndrome	Mecp2 Duplication Syndrome
Mental Retardation, X-Linked, Syndromic, Lubs Type	Mental Retardation, X-Linked, With Recurrent Respiratory Infections
Mrxsl	X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome
Mental Retardation, X-Linked Syndromic, Lubs Type

Gene Duplication Disease

Gene Duplication Syndrome

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Pediatric Systemic Lupus Erythematosus

Sle, Pediatric Onset

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Phototoxic Dermatitis

Dermatitis, Phototoxic	Photosensitisation Reaction
Photosensitive Dermatitis	Photosensitiveness

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Lymphoplasmacytic Lymphoma With Igm Gammopathy	Lymphoplasmacytic Lymphoma
Waldenstrom'S Macroglobulinaemia	Waldenstrom'S Syndrome
Waldenström Macroglobulinemia	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0039	Ginsenoside Rb1	Inhibitor	98.75%	Unkown
HY-103017	JH-X-119-01 hydrochloride	Inhibitor	98.15%	Unkown
HY-147141	HS-276	Inhibitor	98.59%	Unkown
HY-103017A	JH-X-119-01	Inhibitor	≥98.0%	Unkown
HY-111101	AZ1495	Inhibitor	98.18%	Unkown
HY-134911	HS-243	Inhibitor	99.88%	Unkown
HY-153188	JNJ-1013	Degrader	99.80%	Unkown
HY-153110A	Larotinib mesylate hydrate	Inhibitor	98.66%	Unkown
HY-153224	GLPG2534	Inhibitor	98.05%	Unkown
HY-153110	Larotinib	Inhibitor	/	Unkown
HY-160487	KME-2780	Inhibitor	/	Unkown
HY-N0039R	Ginsenoside Rb1 (Standard)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRAK1	MGD	MGI:107420
Canis familiaris	IRAK1	VGNC	VGNC:42087
Rattus norvegicus	IRAK1	RGD	RGD:1563841
Bos taurus	IRAK1	VGNC	VGNC:30264
Macaca mulatta	IRAK1	VGNC	VGNC:73757
Felis catus	IRAK1	VGNC	VGNC:67819
Others	IRAK1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.