1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Trimebutine maleate

Trimebutine maleate 

Cat. No.: HY-B0380A Purity: 99.79%
Handling Instructions

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.

For research use only. We do not sell to patients.

Trimebutine maleate Chemical Structure

Trimebutine maleate Chemical Structure

CAS No. : 34140-59-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Description

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].

Clinical Trial
Molecular Weight

503.54

Formula

C₂₆H₃₃NO₉

CAS No.
SMILES

O=C(O)/C=C\C(O)=O.O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (198.59 mM; Need ultrasonic)

H2O : 25 mg/mL (49.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9859 mL 9.9297 mL 19.8594 mL
5 mM 0.3972 mL 1.9859 mL 3.9719 mL
10 mM 0.1986 mL 0.9930 mL 1.9859 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TrimebutineOpioid ReceptorInhibitorinhibitorinhibit

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Product Name:
Trimebutine maleate
Cat. No.:
HY-B0380A
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