1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. SNC80

SNC80 (Synonyms: NIH 10815)

Cat. No.: HY-101202
Handling Instructions

SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.

For research use only. We do not sell to patients.

SNC80 Chemical Structure

SNC80 Chemical Structure

CAS No. : 156727-74-1

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Description

SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment[1][2][3][4][5][6].

IC50 & Target

IC50: 2.73 nM (δ-opioid receptor), 5457 nM (μ-opioid receptor)[3]
Ki: 1.78 nM (δ-opioid receptor), 881.5 nM (μ-opioid receptor) and 441.8 nM (κ-opioid receptor)[2]

In Vitro

SNC80 selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 exhibits substantially greater activity in cells coexpressing μ- and δ-opioid receptors than in cells either singly expressing δ-opioid receptors or coexpressing δ- and κ-opioid receptors[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SNC80 (10 mg/kg; intraperitoneal injection; once; C57BL6/J mice) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female C57BL6/J mice (20-30g) injected with Sumatriptan[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Significantly attenuated allodynia.
Molecular Weight

449.63

Formula

C₂₈H₃₉N₃O₂

CAS No.

156727-74-1

SMILES

O=C(N(CC)CC)C1=CC=C([[email protected]@H](N2[[email protected]@H](C)CN(CC=C)[[email protected]](C)C2)C3=CC=CC(OC)=C3)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SNC80NIH 10815SNC 80SNC-80NIH10815NIH-10815Opioid ReceptorHeadachesneurologicalnon-peptideantinociceptionδ-opioidG-proteinantihyperalgesicantidepressantInhibitorinhibitorinhibit

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