1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
  2. IRAK
  3. AZ1495

AZ1495 

Cat. No.: HY-111101 Purity: 99.83%
Handling Instructions

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL).

For research use only. We do not sell to patients.

AZ1495 Chemical Structure

AZ1495 Chemical Structure

CAS No. : 2196204-23-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

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Description

AZ1495 (compound 28) is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Shows activity in treatment of mutant MYD88L265P diffuse large B-cell lymphoma (DLBCL)[1].

IC50 & Target[1]

IRAK4

5 nM (IC50)

IRAK1

23 nM (IC50)

CLK1

50 nM (IC50)

CLK2

5 nM (IC50)

CLK4

8 nM (IC50)

haspin

4 nM (IC50)

Molecular Weight

385.50

Formula

C₂₁H₃₁N₅O₂

CAS No.

2196204-23-4

SMILES

C1(C(C2CCOCC2)=CN3)=C3N=CN=C1N[[email protected]@H]4CC[[email protected]@H](N5CCOCC5)CC4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (25.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5940 mL 12.9702 mL 25.9403 mL
5 mM 0.5188 mL 2.5940 mL 5.1881 mL
10 mM 0.2594 mL 1.2970 mL 2.5940 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (2.59 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.83%

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Product Name:
AZ1495
Cat. No.:
HY-111101
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