IRAK1-IN-2
IRAK1-IN-2 is an orally active IRAK1 inhibitor and antitumor agent with high selectivity for IRAK4 and other kinases in the same group. IRAK1-IN-2 functionally inhibits IRAK1 and interferes with the TLR/IL-1R signaling pathway. IRAK1-IN-2 suppresses hepatocellular carcinoma-related cellular processes in vitro and in animal models. IRAK1-IN-2 serves as a chemical probe for IRAK1 research and is applicable to studies on hepatocellular carcinoma.
For research use only. We do not sell to patients.
- Formula: C29H29F3N4O4
- Molecular Weight:554.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IRAK1 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice with Hepatocellular carcinoma[1]
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Dosage:20 mg/kg; 40 mg/kg
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Administration:p.o.; once daily; 16 days
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Result:Achieved a 51.1% tumor growth inhibition rate at 20 mg/kg.
Achieved a 70.3% tumor growth inhibition rate at 40 mg/kg.
Showed no significant differences in body weight between treatment groups and controls during the study period.
Significantly reduced levels of phosphorylated IRAK1 and phosphorylated STAT3 in harvested tumor tissue.
Revealed no obvious pathological lesions in major organs at either dose.
Chemical Information
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Molecular Weight 554.56
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Formula C29H29F3N4O4
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SMILES
O=C1C=CC(C2=CC(C(F)(F)F)=CC=C2)=NN1CCOC3=C4C=CC(OCCCN5CCOCC5)=CC4=NC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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