IRAK1-IN-2
IRAK1-IN-2 is an orally active IRAK1 inhibitor and antitumor agent with high selectivity for IRAK4 and other kinases in the same group. IRAK1-IN-2 functionally inhibits IRAK1 and interferes with the TLR/IL-1R signaling pathway. IRAK1-IN-2 suppresses hepatocellular carcinoma-related cellular processes in vitro and in animal models. IRAK1-IN-2 serves as a chemical probe for IRAK1 research and is applicable to studies on hepatocellular carcinoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C29H29F3N4O4
- Peso molecular:554.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
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IRAK1 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude mice with Hepatocellular carcinoma[1]
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Dosage:20 mg/kg; 40 mg/kg
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Administration:p.o.; once daily; 16 days
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Result:Achieved a 51.1% tumor growth inhibition rate at 20 mg/kg.
Achieved a 70.3% tumor growth inhibition rate at 40 mg/kg.
Showed no significant differences in body weight between treatment groups and controls during the study period.
Significantly reduced levels of phosphorylated IRAK1 and phosphorylated STAT3 in harvested tumor tissue.
Revealed no obvious pathological lesions in major organs at either dose.
Chemical Information
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Peso molecular 554.56
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Fòrmula C29H29F3N4O4
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SMILES
O=C1C=CC(C2=CC(C(F)(F)F)=CC=C2)=NN1CCOC3=C4C=CC(OCCCN5CCOCC5)=CC4=NC=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IRAK1-IN-2 Related Classifications
HY-181712 Related Classifications
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