IRF7 - interferon regulatory factor 7 Gene

Also Known as IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3665

About IRF7

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:612,555-615,950 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 203 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues.

Summary

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

IRF7 Products (3)

mRNA	Protein	Name
NM_001572.5	NP_001563.2	interferon regulatory factor 7 isoform a
NM_004029.4	NP_004020.1	interferon regulatory factor 7 isoform b
NM_004031.4	NP_004022.2	interferon regulatory factor 7 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	12374802	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17404045	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17404045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11943871	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	21931555	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12374802	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22065573	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	17404045	GOA
involved in regulation of adaptive immune response	IDA IDA: Inferred from direct assay	17404045	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	11473119	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19176627	GOA
located in cytoplasm	IGI IGI: Inferred from genetic interaction	23729669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22065573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF7 Protein Structure

IRF

IRF-3

0
100
200
300
400
503 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 7	interferon regulatory factor-7H

IRF7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRF7	Q92985	LTN1	Homo sapiens	O94822	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TLK2	Homo sapiens	Q86UE8	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TRMT61B	Homo sapiens	Q9BVS5	Pull Down	30833792
Intra	IRF7	Q92985	TRMT61B	Homo sapiens	Q9BVS5	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TBK1	Homo sapiens	Q9UHD2	Y2H	17599067
Intra	IRF7	Q92985	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	ARAF	Homo sapiens	P10398	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	PALD1	Homo sapiens	Q9ULE6	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	AIP	Homo sapiens	O00170	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422
Cross	IRF7	Q92985	ORF45	Human herpesvirus 8	F5HDE4	Y2H	11943871
Cross	IRF7	Q92985	ORF45	Human herpesvirus 8	F5HDE4	Pull Down	11943871
Cross	IRF7	Q92985	P	Measles virus	Q77M19	Pull Down	18922877

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82718	IRF7 Antibody (YA2463)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
HY-P82718A	IRF7 Antibody (YA2463)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 39	IMD39 Immunodeficiency, Type 39
Predisposition To Severe Viral Infection Due To Irf7 Deficiency
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Vaccinia
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Rabies	Lyssa Hydrophobia St Hubert Disease
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Oral Hairy Leukoplakia	Hairy Leukoplakia Leukoplakia, Hairy Hairy Leucoplakia
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-176426	Subquinocin		99.83%	Phase 4

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146244	Agatolimod		98.84%	Unkown
HY-150741C	ODN 2216 sodium	Agonist	98.57%	Unkown
HY-150741	ODN 2216		98.57%	Unkown
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-P11072	IRF5-CPP5	Inhibitor	99.23%	Unkown
HY-150750A	ODN M362 sodium		97.02%	Unkown
HY-117066	CL075	Agonist	99.18%	Unkown
HY-122891	SB02024		99.70%	Unkown
HY-RS06911	IRF7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162465	BDW568	Agonist	99.4%	Unkown
HY-RS16952	Irf7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184488	AT-1965	Inhibitor	/	Unkown
HY-178690	MyD88-IN-4	Inhibitor	/	Unkown
HY-174663	Human IFNE mRNA		/	Unkown
HY-RS23395	Irf7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRF7	MGD	MGI:1859212
Macaca mulatta	IRF7	VGNC	VGNC:73765
Felis catus	IRF7	VGNC	VGNC:67829
Rattus norvegicus	IRF7	RGD	RGD:1307828
Bos taurus	IRF7	VGNC	VGNC:30278
Others	IRF7	NCBI