AIP - aryl hydrocarbon receptor interacting protein Gene

Homo sapiens

Also known as ARA9; XAP2; PITA1; XAP-2; FKBP16; FKBP37; SMTPHN

Gene ID: 9049 | Gene type: protein coding

About AIP

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,483,026-67,491,103 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues, 1 paralogue and is associated with 8 phenotypes. Ubiquitous expression in lymph node (RPKM 29.1), spleen (RPKM 26.1) and 25 other tissues.

Summary

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

AIP Products(3)

mRNA	Protein	Name
NM_001302959.2	NP_001289888.1	AH receptor-interacting protein isoform 2
NM_001302960.2	NP_001289889.1	AH receptor-interacting protein isoform 3
NM_003977.4	NP_003968.3	AH receptor-interacting protein isoform 1

AIP Protein Structure

FKBP_C

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

AH receptor-interacting protein

Ah receptor activated 9

Related Diseases

Diseases

Alias

Pituitary Adenoma 1, Multiple Types

Pituitary Adenoma Predisposition	PITA1
Isolated Familial Somatotropinoma	Fis
Ifs	Somatotrophinoma, Familial
Acromegaly Due To Pituitary Adenoma 1	Pagh1
Pituitary Adenoma 1	Somatotropinoma, Familial Isolated
Somatotropic Adenoma	Somatotropinoma
Pituitary Gigantism	Hypophyseal Gigantism
Infantile And Juvenile Forms Of Acromegaly	Acromegaly Due To Pituitary Adenoma
Familial Isolated Pituitary Adenoma	Familial Isolated Somatotropinomas
Familial Somatotrophinoma	Fipa
Pituitary Adenoma, Growth Hormone-Secreting, 1	Gigantism Pituitary
Pituitary Adenoma, Type 1, Multiple Types	Gigantism
Pituitary Adenoma, Familial Isolated	Multiple Gastrointestinal Atresias

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Gastrointestinal Defects And Immunodeficiency Syndrome 1

Familial Intestinal Polyatresia Syndrome	Fipa
Gastrointestinal Defects And Immunodeficiency Syndrome	Multiple Gastrointestinal Atresias
Familial Isolated Pituitary Adenoma	Intestinal Atresia, Multiple
Multiple Intestinal Atresia	GIDID1
Multiple Intestinal Atresia And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Minat
Gidid	Meddra:10028210
Familial Isolated Pituitary Adenoma Syndrome	Intestinal Atresia Multiple
Combined Immunodeficiency-Enteropathy Spectrum	Cid-Mia/Early-Onset Ibd
Intestinal Atresia, Multiple And/Or Inflammatory Bowel Disease With Or Without Immunodeficiency	Mia
Gastrointestinal Defect And Immunodeficiency Syndrome	Pituitary Adenoma Predisposition
Pituitary Adenoma, Familial Isolated

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Silent Pituitary Adenoma

Non-Functioning Pituitary Gland Neoplasm

Null Pituitary Adenoma

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor	Pituitary Tumors, Hormone Producing
Somatotropinoma	Growth Hormone-Producing Pituitary Gland Neoplasm

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Pituitary Adenoma

Adenoma Of The Pituitary Gland	Pituitary Adenomas
Adenoma, Pituitary	Pituitary Gland Adenoma
Pituitary Neoplasms

Pituitary Apoplexy

Pituitary Tumor Apoplexy

Pituitary Cancer

Pituitary Carcinoma	Malignant Pituitary Neoplasm
Malignant Tumor Of Pituitary Gland	Neoplasm Of Pituitary Gland
Pituitary Gland Cancer	Pituitary Gland Neoplasm
Pituitary Neoplasm	Carcinoma Of The Pituitary Gland
Neoplasm Of The Pituitary Gland	Pituitary Neoplasms
Malignant Neoplasm Of Pituitary Gland

Lissencephaly, X-Linked, 2

X-Linked Lissencephaly With Abnormal Genitalia	Hydranencephaly With Abnormal Genitalia
Xlag	Xlisg
X-Linked Lissencephaly With Ambiguous Genitalia	LISX2
Lissencephaly, X-Linked 2	X-Linked Lissencephaly 2
X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome	Xlag Syndrome
Lissencephaly, X-Linked, With Ambiguous Genitalia	Xlis2
X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies	X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome
Xlag Syndrome	Lissencephaly X-Linked With Ambiguous Genitalia
Lissencephaly, X-Linked, Type 2	Chromosome Xq26.3 Duplication Syndrome

Carney Complex Variant

Carney Complex	Carney Syndrome
Carney Complex, Type 1	Lamb Syndrome
Name Syndrome	Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome
Carney Complex - Trismus - Pseudocamptodactyly Syndrome	Carney Complex, Type 2
Car	Cnc1
Carney Myxoma-Endocrine Complex	Myxoma - Spotty Pigmentation - Endocrine Overactivity
Myxoma, Spotty Pigmentation, And Endocrine Overactivity	Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome
Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome	Carney Complex-Trismus-Pseudocamptodactyly Syndrome
CACOV

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Hyperpituitarism

Pituitary Infarct

Pituitary Infarction

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4	MEN4
Multiple Endocrine Neoplasia 4	Neoplasia, Endocrine, Multiple, Type Iv

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism	Hyperparathyroidism, Primary
Hyperparathyroidism Primary	Hypocalciuric Hypercalcemia, Familial, Type 1
Familial Benign Hypercalcemia	Familial Hyperparathyroidism
Parathyroid Enlargement

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Tsh Producing Pituitary Tumor

Thyrotroph Adenoma	Tsh Producing Pituitary Tumour
Tsh Secreting Adenoma Of The Pituitary	Tsh Secreting Tumor Of Pituitary
Tsh Secreting Tumour Of Pituitary	Tsh-Secreting Pituitary Adenoma
Pituitary Thyrotrophic Adenoma	Tsh-Oma
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma	Thyroid Stimulating Hormone-Producing Pituitary Tumor

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma	Corticotroph Adenoma
Corticotropinoma	Pituitary-Dependent Cushing'S Disease
Adrenal Gland Hyperfunction	Cushing Syndrome

Mccune-Albright Syndrome

Mass Syndrome	Polyostotic Fibrous Dysplasia
MAS	Fibrous Dysplasia Of Bone
Albright Syndrome	Mass Phenotype
Overlap Connective Tissue Disease	Mccune Albright Syndrome
Osteitis Fibrosa Disseminata	OCTD
Albright'S Disease	Pfd
Pofd	Albright'S Syndrome
Mccune-Albright Syndrome, Somatic, Mosaic	Albright'S Disease Of Bone
Albright'S Syndrome With Precocious Puberty	Albright-Mccune-Sternberg Syndrome
Albright-Sternberg Syndrome	Fibrous Dysplasia With Pigmentary Skin Changes And Precocious Puberty
Gonadotropin-Independent Female-Limited Sexual Precocity	Fibrous Dysplasia Polyostotic
Fibrous Dysplasia, Polyostotic

Endocrine Organ Benign Neoplasm

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00499	AIP Human Pre-designed siRNA Set A	/	Unkown
HY-RS02415	CDKN2AIP Human Pre-designed siRNA Set A	/	Unkown
HY-RS04442	EPM2AIP1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS14904	TOR1AIP1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS14905	TOR1AIP2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS14914	TP53AIP1 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	AIP	VGNC	VGNC:69759
Rattus norvegicus	AIP	RGD	RGD:628619
Felis catus	AIP	VGNC	VGNC:59703
Canis familiaris	AIP	VGNC	VGNC:37741
Mus musculus	AIP	MGD	MGI:109622
Bos taurus	AIP	VGNC	VGNC:25767
Others	AIP	NCBI

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