Autoinducing Peptide I
Based on 1 Customer Validation
Autoinducing Peptide I (AIP-I) is a competitive AgrC antagonist and AgrC I activator. By blocking AIP-AgrC interaction and agr quorum sensing signaling, it inhibits MRSA agr-I and agr-III and protects the mouse skin barrier. Autoinducing Peptide I can be used in research on Staphylococcus aureus infection.
For research use only. We do not sell to patients.
- Purity : 99.25%
- CAS No.: 200010-29-3
- Formula: C43H60N8O13S2
- Molecular Weight:961.11
-
Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Autoinducing Peptide I (AIP-I) inhibits biofilm formation in S. aureus JE2 but not in the agrA mutant JE2 agrA::tn[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 200010-29-3
-
Appearance Solid
-
Molecular Weight 961.11
-
Formula C43H60N8O13S2
-
Color White to off-white
-
Synonyms
AIP-I
-
Sequence
Tyr-Ser-Thr-Cys-Asp-Phe-Ile-Met (Thioester bridge:Cys4-Met8)
-
Sequence Shortening
YSTCDFIM (Thioester bridge:Cys4-Met8)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (104.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0405 mL | 5.2023 mL | 10.4046 mL | 26.0116 mL |
| 5 mM | 0.2081 mL | 1.0405 mL | 2.0809 mL | 5.2023 mL | |
| 10 mM | 0.1040 mL | 0.5202 mL | 1.0405 mL | 2.6012 mL | |
| 15 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7341 mL | |
| 20 mM | 0.0520 mL | 0.2601 mL | 0.5202 mL | 1.3006 mL | |
| 25 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0405 mL | |
| 30 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8671 mL | |
| 40 mM | 0.0260 mL | 0.1301 mL | 0.2601 mL | 0.6503 mL | |
| 50 mM | 0.0208 mL | 0.1040 mL | 0.2081 mL | 0.5202 mL | |
| 60 mM | 0.0173 mL | 0.0867 mL | 0.1734 mL | 0.4335 mL | |
| 80 mM | 0.0130 mL | 0.0650 mL | 0.1301 mL | 0.3251 mL | |
| 100 mM | 0.0104 mL | 0.0520 mL | 0.1040 mL | 0.2601 mL |
Autoinducing Peptide I Related Classifications
HY-P4909 Related Classifications
Powered by Bioz