200010-29-3
Chemical Structure
Autoinducing Peptide I
Synonym(s): AIP-I
- CAS No.: 200010-29-3
- Formula:C43H60N8O13S2
- Molecular Weight:961.11
InChIKey: QPIROHVZMLYRNN-YRNJLPRFSA-N
SMILES: O=C([C@@H](NC([C@H](CSC([C@@H](NC([C@](NC1=O)([H])[C@@H](C)CC)=O)CCSC)=O)NC([C@H]([C@H](O)C)NC([C@H](CO)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)CC(O)=O)N[C@H]1CC3=CC=CC=C3
Biological Activity: Autoinducing Peptide I (AIP-I) is a competitive AgrC antagonist and AgrC I activator. By blocking AIP-AgrC interaction and agr quorum sensing signaling, it inhibits MRSA agr-I and agr-III and protects the mouse skin barrier. Autoinducing Peptide I can be used in research on Staphylococcus aureus infection[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Autoinducing Peptide I | 99.25% | Autoinducing Peptide I (AIP-I) is a competitive AgrC antagonist and AgrC I activator. By blocking AIP-AgrC interaction and agr quorum sensing signaling, it inhibits MRSA agr-I and agr-III and protects the mouse skin barrier. Autoinducing Peptide I can be used in research on Staphylococcus aureus infection. | ||||||||||||||||||||
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References
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[1]. Troy D, et al. A small molecule dual inhibitor of agr quorum sensing and ATP synthase blocks acute and chronic virulence phenotypes in Staphylococcus aureus. ChemRxiv. 03 April 2026.
- [2]. Martínez OF, et al. Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens. Frontiers in microbiology. 2022;13:831037.
- [3]. Severn MM, et al. The Ubiquitous Human Skin Commensal Staphylococcus hominis Protects against. mBio, 13 (3). 2022 Jun 28.
- [4]. Gless BH, et al. Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching. Angewandte Chemie International Edition. 2026 Jul 23:e9489770.
- [5]. Spangler JR, et al. Promoter Identification and Optimization for the Response of Lactobacillus plantarum WCFS1 to the Gram-Negative Pathogen-Associated Molecule N‑3-Oxododecanoyl Homoserine Lactone. ACS Biomaterials Science & Engineering. 2023 Sep 11;9(9):5111-22.
- [6]. Li Y, et al. Nitrate Reductase NarGHJI Modulates Virulence via Regulation of Expression in Methicillin-Resistant Strain USA300 LAC. Microbiology spectrum. 2023 Jun 15;11(3):e0359622.
