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TLK2 - tousled like kinase 2 Gene

Also Known as HsHPK; MRD57; PKU-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11011

About TLK2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,470,914-62,615,481 (from NCBI)

This gene has 32 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TLK2 Products (10)

mRNA	Protein	Name
NM_001284333.3	NP_001271262.1	serine/threonine-protein kinase tousled-like 2 isoform C
NM_001284363.1	NP_001271292.1	serine/threonine-protein kinase tousled-like 2 isoform B
NM_001330418.3	NP_001317347.1	serine/threonine-protein kinase tousled-like 2 isoform D
NM_001375269.1	NP_001362198.1	serine/threonine-protein kinase tousled-like 2 isoform E
NM_001375270.1	NP_001362199.1	serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375271.1	NP_001362200.1	serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375272.1	NP_001362201.1	serine/threonine-protein kinase tousled-like 2 isoform B
NM_001375273.1	NP_001362202.1	serine/threonine-protein kinase tousled-like 2 isoform D
NM_001411074.1	NP_001398003.1	serine/threonine-protein kinase tousled-like 2 isoform F
NM_006852.6	NP_006843.2	serine/threonine-protein kinase tousled-like 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12660173	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12660173	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	12660173	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	12660173	GOA
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	20705056	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12660173	GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20016786	GOA
involved in nucleus localization	IMP IMP: Inferred from mutant phenotype	29955062	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20016786	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12660173	GOA
involved in regulation of chromatin organization	IDA IDA: Inferred from direct assay	12660173	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in intermediate filament	IDA IDA: Inferred from direct assay	10455159	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9427565	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10455159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLK2 Protein Structure

Pkinase

0
200
400
600
772 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase tousled-like 2

TLK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TLK2	Q86UE8	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	TLK2	Q86UE8	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	DYNLL1	Homo sapiens	P63167	Pull Down	32707033
Intra	TLK2	Q86UE8	TLK1	Homo sapiens	Q9UKI8	Anti Tag CoIP	33961781
Intra	TLK2	Q86UE8	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	35271311
Intra	TLK2	Q86UE8	TLK1	Homo sapiens	Q9UKI8	Pull Down	32707033
Intra	TLK2	Q86UE8	TLK1	Homo sapiens	Q9UKI8	BioID	33323470
Intra	TLK2	Q86UE8	DYNLL2	Homo sapiens	Q96FJ2	BioID	33323470
Intra	TLK2	Q86UE8	DYNLL1	Homo sapiens	P63167	BioID	33323470
Intra	TLK2	Q86UE8	DYNLL1	Homo sapiens	P63167	Pull Down	33323470
Intra	TLK2	Q86UE8	DYNLL2	Homo sapiens	Q96FJ2	Pull Down	32707033
Intra	TLK2	Q86UE8	TLK1	Homo sapiens	Q9UKI8	Pull Down	33323470
Intra	TLK2	Q86UE8	FRMD6	Homo sapiens	Q96NE9-2	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	FRMD6	Homo sapiens	Q96NE9-2	Validated Y2H	32296183
Intra	TLK2	Q86UE8	FRMD6	Homo sapiens	Q96NE9-2	Y2H Array	32296183
Intra	TLK2	Q86UE8	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	TLK2	Q86UE8	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	TLK2	Q86UE8	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	TLK2	Q86UE8	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	SMARCC2	Homo sapiens	Q8TAQ2	Anti Bait CoIP	36950384
Intra	TLK2	Q86UE8	DMAP1	Homo sapiens	Q9NPF5	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	DMAP1	Homo sapiens	Q9NPF5	Validated Y2H	32296183
Intra	TLK2	Q86UE8	DMAP1	Homo sapiens	Q9NPF5	Y2H Array	32296183
Intra	TLK2	Q86UE8	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	TLK2	Q86UE8	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	TLK2	Q86UE8	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	TLK2	Q86UE8	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	TLK2	Q86UE8	ASF1A	Homo sapiens	Q9Y294	BioID	33323470
Intra	TLK2	Q86UE8	ASF1A	Homo sapiens	Q9Y294	Pull Down	33323470
Intra	TLK2	Q86UE8	IRF7	Homo sapiens	Q92985	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 57	Mental Retardation, Autosomal Dominant 57 MRD57
Pica Disease	Pica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162426	UNC-CA2-103	Inhibitor	99.26%	Unkown
HY-149213	LSD1/TLK1-IN-1	Inhibitor	99.20%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLK2	RGD	RGD:1310907
Mus musculus	TLK2	MGD	MGI:1346023
Felis catus	TLK2	VGNC	VGNC:66212
Bos taurus	TLK2	VGNC	VGNC:35894
Macaca mulatta	TLK2	VGNC	VGNC:78368
Canis familiaris	TLK2	VGNC	VGNC:47399
Others	TLK2	NCBI