TLK2 - tousled like kinase 2 Gene

Homo sapiens

Also known as HsHPK; MRD57; PKU-ALPHA

Gene ID: 11011 | Gene type: protein coding

About TLK2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,470,914-62,615,481 (from NCBI)

This gene has 32 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 14.1), bone marrow (RPKM 5.4) and 25 other tissues.

Summary

This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

TLK2 Products(10)

mRNA	Protein	Name
NM_001284333.3	NP_001271262.1	serine/threonine-protein kinase tousled-like 2 isoform C
NM_001284363.1	NP_001271292.1	serine/threonine-protein kinase tousled-like 2 isoform B
NM_001330418.3	NP_001317347.1	serine/threonine-protein kinase tousled-like 2 isoform D
NM_001375269.1	NP_001362198.1	serine/threonine-protein kinase tousled-like 2 isoform E
NM_001375270.1	NP_001362199.1	serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375271.1	NP_001362200.1	serine/threonine-protein kinase tousled-like 2 isoform A
NM_001375272.1	NP_001362201.1	serine/threonine-protein kinase tousled-like 2 isoform B
NM_001375273.1	NP_001362202.1	serine/threonine-protein kinase tousled-like 2 isoform D
NM_001411074.1	NP_001398003.1	serine/threonine-protein kinase tousled-like 2 isoform F
NM_006852.6	NP_006843.2	serine/threonine-protein kinase tousled-like 2 isoform A

TLK2 Protein Structure

Pkinase

0
200
400
600
772 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase tousled-like 2

Recombinant TLK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76106	TLK2 Protein, Human (sf9)	Q86UE8 (L397-N772)	≥95%
HY-P76107	TLK2 Protein, Human (sf9, His-GST)	Q86UE8 (L397-N772)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 57

Mental Retardation, Autosomal Dominant 57

MRD57

Pica Disease

Pica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14571	TLK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLK2	RGD	RGD:1310907
Mus musculus	TLK2	MGD	MGI:1346023
Felis catus	TLK2	VGNC	VGNC:66212
Bos taurus	TLK2	VGNC	VGNC:35894
Macaca mulatta	TLK2	VGNC	VGNC:78368
Canis familiaris	TLK2	VGNC	VGNC:47399
Others	TLK2	NCBI