PALD1 - phosphatase domain containing paladin 1 Gene

Also Known as PALD; KIAA1274

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27143

About PALD1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:70,458,485-70,568,450 (from NCBI)

This gene has 14 transcripts (splice variants), 213 orthologues and 8 paralogues. Ubiquitous expression in lung (RPKM 5.3), spleen (RPKM 4.7) and 24 other tissues.

Summary

Predicted to enable protein tyrosine Phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PALD1 Products (1)

mRNA Protein Name
NM_014431.3 NP_055246.2 paladin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
22354871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALD1 Protein Structure

PTPlike_phytase

PTPlike_phytase: Inositol hexakisphosphate (161 - 329)

PTPlike_phytase

PTPlike_phytase: Inositol hexakisphosphate (545 - 677)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 856 a.a.
Protein Preferred Names Protein Names

paladin

  • palladin

PALD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PALD1 Q9ULE6 IRF7 Homo sapiens Q92985
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alzheimer Disease 7

  • Ad7

  • Alzheimer'S Disease 7

  • Alzheimer Disease, Familial, 7

  • Alzheimer Disease-7

  • Alzheimer Disease, Familial 7
Atrial Septal Defect 6

  • ASD6

  • Atrial Heart Septal Defect 6

  • Septal Defect, Atrial, Type 6
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10003 PALD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PALD1 RGD RGD:1305933
Canis familiaris PALD1 VGNC VGNC:44246
Felis catus PALD1 VGNC VGNC:64028
Macaca mulatta PALD1 VGNC VGNC:75670
Mus musculus PALD1 MGD MGI:1351623
Bos taurus PALD1 VGNC VGNC:50088
Others PALD1 NCBI