2. PI3K/Akt/mTOR Immunology/Inflammation GPCR/G Protein JAK/STAT Signaling Stem Cell/Wnt
  3. PI3K CXCR STAT
  4. SB02024

SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity.

For research use only. We do not sell to patients.

SB02024 Chemical Structure

SB02024 Chemical Structure

CAS No. : 2126737-28-6

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SB02024 Related Antibodies

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Description

SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].

IC50 & Target

Vps34

 

STAT1

 

In Vitro

SB02024 (5 μM, 48 h) induces CCL5 and CXCL10 via STAT1/IRF7 in B16-F10 and CT26 tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SB02024 Related Antibodies

Western Blot Analysis[1]

Cell Line: B16-F10 and CT26 tumor cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly up-regulates both Ccl5/Rantes and Cxcl10/IP10 mRNA and their corresponding secreted protein levels in YUMM cells, B16-F10 and CT26 tumor cells. Showed an induction of phospho-signal transducer and activator of transcription 1 (pSTAT1) and increased protein and mRNA expression of STAT1, IRF1 and IRF7.
In Vivo

SB02024 (20 mg/kg, Oral gavage) decreases the tumor growth and improves the effect benefit of anti-PD-L1/PD-1[1].
SB02024 increases the levels of CCL5 and CXCL10 in the blood plasma of B16-F10 and CT26 tumor-bearing mice, but dose not increase CCL5 or CXCL10 levels in the blood of non-tumor-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, BALB/C, immunodeficient NSG mice (7 weeks old)[1]
Dosage: 20 mg/kg
Administration: Oral gavage
Result: Decreased the tumor growth and weight of B16-F10 and CT26 and prolonged the survival of tumor-bearing mice.
Molecular Weight

345.36

Formula

C16H22F3N3O2
CAS No.
SMILES

O=C1C=C(N2[C@H](C)COCC2)C=C(N3[C@@H](C(F)(F)F)CCCC3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SB02024 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB020242126737-28-6SB 02024SB-02024PI3KCXCRSTATPhosphoinositide 3-kinaseCXC chemokine receptorsC-X-C motif chemokine receptorsB16-F10CT26 tumor cellsYUMM cellsorally activeInhibitorinhibitorinhibit

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