2126737-28-6
2126737-28-6
Chemical Structure
SB02024
- CAS No.: 2126737-28-6
- Formula:C16H22F3N3O2
- Molecular Weight:345.36
IUPAC Name: 4-((R)-3-methylmorpholino)-6-((R)-2-(trifluoromethyl)piperidin-1-yl)pyridin-2(1H)-one
InChIKey: IARAUFAUVKBTEM-DGCLKSJQSA-N
SMILES: O=C1C=C(N2[C@H](C)COCC2)C=C(N3[C@@H](C(F)(F)F)CCCC3)N1
Biological Activity: SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB02024 | 99.70% | SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity. | ||||||||||||||||||||
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References
- [1]. Noman MZ, et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci Adv. 2020 Apr 29;6(18):eaax7881. [Content Brief]
- [2]. Yu Y, et al. Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol. 2024 Mar 20. [Content Brief]
- [3]. Bassam Claude JANJI, et al. Biomarker. Patent WO2020008046 A1.
Keywords
