TRMT61B - tRNA methyltransferase 61B Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55006

About TRMT61B

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,849,821-28,870,309 (from NCBI)

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.4), small intestine (RPKM 6.4) and 25 other tissues.

Summary

Enables mRNA (adenine-N1-)-methyltransferase activity; rRNA (adenine) methyltransferase activity; and tRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation; mitochondrial tRNA methylation; and protein homooligomerization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

TRMT61B Products (1)

mRNA	Protein	Name
NM_017910.4	NP_060380.3	tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mRNA (adenine-N1-)-methyltransferase activity	IDA IDA: Inferred from direct assay	29107537	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables rRNA (adenine) methyltransferase activity	IMP IMP: Inferred from mutant phenotype	27631568	GOA
enables tRNA (adenine(58)-N1)-methyltransferase activity	IDA IDA: Inferred from direct assay	23097428	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA processing	IDA IDA: Inferred from direct assay	29107537	GOA
involved in mitochondrial tRNA processing	IDA IDA: Inferred from direct assay	23097428	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	27184847	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	23097428	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT61B Protein Structure

GCD14

0
100
200
300
400
477 a.a.

Protein Preferred Names	Protein Names
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial	mRNA methyladenosine-N(1)-methyltransferase

TRMT61B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRMT61B	Q9BVS5	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
Intra	TRMT61B	Q9BVS5	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	TRMT61B	Q9BVS5	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency	MCC1D Mccd Type 1 Mcc1 Deficiency Methylcrotonylglycinuria Type I 3-Methylcrotonylglycinuria I 3-Methylcrotonoyl-Coa Carboxylase 1 Deficiency 3-Methylcrotonylglycinuria Type I Mcgi 3 Methylcrotonyl-Coa Carboxylase 1 Deficiency 3-Methylcrotonyl Coa Carboxylase 1 Deficiency
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15096	TRMT61B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21266	Trmt61b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown