1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. CL075

CL075 (Synonyms: 3M002)

Cat. No.: HY-117066
Handling Instructions

CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.

For research use only. We do not sell to patients.

CL075 Chemical Structure

CL075 Chemical Structure

CAS No. : 256922-53-9

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Description

CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively[1][2][3].

IC50 & Target

TLR8[1]

In Vitro

CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes[1].
CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes[1].
CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

243.33

Formula

C₁₃H₁₃N₃S

CAS No.

256922-53-9

SMILES

NC1=NC2=CC=CC=C2C(S3)=C1N=C3CCC

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CL0753M002CL 075CL-075Toll-like Receptor (TLR)TLR8immunomodulatinginflammatorycytokinesIFNsNF-κBIRF7Inhibitorinhibitorinhibit

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CL075
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HY-117066
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