2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. CL075

CL075  (Synonyms: 3M002)

Cat. No.: HY-117066 Purity: 99.25%
COA Handling Instructions

CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.

For research use only. We do not sell to patients.

CL075 Chemical Structure

CL075 Chemical Structure

CAS No. : 256922-53-9

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 105 In-stock
Solution
10 mM * 1 mL in DMSO USD 105 In-stock
Solid
5 mg USD 95 In-stock
10 mg USD 160 In-stock
25 mg USD 350 In-stock
50 mg USD 550 In-stock
100 mg USD 950 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

CL075 Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively[1][2][3].

IC50 & Target

TLR8

 

In Vitro

CL075 (2 μM; 4 h) induces the production of IL-6, IL-8, and IFN-γ in rabbit splenocytes[1].
CL075 (2 μM; 48 h) induces the total IgM production and cell proliferation in rabbit splenocytes[1].
CL075 (2 μM; 7 h) activates the rabTLR8 in 293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CL075 Related Antibodies
In Vivo

CL075 (5 μM (0.5 mL); s.c.) activates a mild antigen-specific antibody response in rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

243.33

Appearance

Solid

Formula

C13H13N3S
CAS No.
SMILES

NC1=NC2=CC=CC=C2C(S3)=C1N=C3CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 22 mg/mL (90.41 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1096 mL 20.5482 mL 41.0965 mL
5 mM 0.8219 mL 4.1096 mL 8.2193 mL
10 mM 0.4110 mL 2.0548 mL 4.1096 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.25%

COA (253 KB) HNMR (160 KB) RP-HPLC (194 KB)

Handling Instructions (2659 KB)
References
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CL075 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CL075256922-53-93M002CL 075CL-075Toll-like Receptor (TLR)TLR8immunomodulatinginflammatorycytokinesIFNsNF-κBIRF7Inhibitorinhibitorinhibit

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