256922-53-9
256922-53-9
Chemical Structure
CL075
Synonym(s): 3M002
- CAS No.: 256922-53-9
- Formula:C13H13N3S
- Molecular Weight:243.33
IUPAC Name: 2-propylthiazolo[4,5-c]quinolin-4-amine
InChIKey: NFYMGJSUKCDVJR-UHFFFAOYSA-N
SMILES: NC1=NC2=CC=CC=C2C(S3)=C1N=C3CCC
Biological Activity: CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively[1][2][3].
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CL075 | 99.18% | CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively. | ||||||||||||||||||||
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References
- [1]. Lai CY, et, al. TLR7/8 agonists activate a mild immune response in rabbits through TLR8 but not TLR7. Vaccine. 2014 Sep 29;32(43):5593-9. [Content Brief]
- [2]. Spranger S, et, al. Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J Immunol. 2010 Jul 1;185(1):738-47. [Content Brief]
- [3]. Maalej KM, et, al. TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils. J Leukoc Biol. 2015 Jun;97(6):1081-7. [Content Brief]
Keywords
