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Referencia número: HY-125142

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AP-24567

AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342).

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 943319-87-7
Fòrmula: C₂₈H₂₅F₃N₆O
Peso molecular:518.53

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

AP-24567 Chemical Structure

No. CAS: 943319-87-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

AP-24567 is a Ligands for Target Protein for PROTAC, which can be used for the synthesis of SB1-G-187 (HY-137342)^[1].

IC₅₀ & Target

Lyn

Yes

IRAK1

Ver todos los productos específicos de isoformas Src :

Ver todos los productos específicos de isoformas VEGFR :

Ver todos los productos específicos de isoformas Bcr-Abl :

Abl
Bcr-Abl

Ver todos los productos específicos de isoformas PDGFR :

Ver todos los productos específicos de isoformas IRAK :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	34 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	4 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	915 nM Compound: 20j	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 20513156]

In Vitro

AP-24567 is a PROTAC-targeted protein ligand^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 943319-87-7
Peso molecular 518.53
Fòrmula C₂₈H₂₅F₃N₆O
SMILES

O=C(NC1=CC=C(CN2CCNCC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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Cantidad:
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AP-24567

Ver todos los productos específicos de isoformas Src

Ver todos los productos específicos de isoformas VEGFR

Ver todos los productos específicos de isoformas Bcr-Abl

Ver todos los productos específicos de isoformas PDGFR

Ver todos los productos específicos de isoformas IRAK

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

AP-24567 Related Classifications

HY-125142 Related Classifications