IRF4 - interferon regulatory factor 4 Gene

Also Known as MUM1; LSIRF; SHEP8; NF-EM5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3662

About IRF4

Cytogenetic location: 6p25.3 Genomic coordinates (GRCh38): 6:391,752-411,443 (from NCBI)

This gene has 8 transcripts (splice variants), 220 orthologues, 8 paralogues and is associated with 79 phenotypes. Broad expression in lymph node (RPKM 13.5), bone marrow (RPKM 12.6) and 14 other tissues.

Summary

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to Infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

IRF4 Products (2)

mRNA Protein Name
NM_001195286.2 NP_001182215.1 interferon regulatory factor 4 isoform 2
NM_002460.4 NP_002451.2 interferon regulatory factor 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12374808 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12374808 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21903422 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12374808 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
12374808 GOA
involved in positive regulation of interleukin-13 production IDA
IDA: Inferred from direct assay
12374808 GOA
involved in positive regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
12374808 GOA
involved in positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
12374808 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12374808 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF4 Protein Structure

IRF

IRF: Interferon regulatory factor transcription factor (23 - 129)

IRF-3

IRF-3: Interferon-regulatory factor 3 (249 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 451 a.a.
Protein Preferred Names Protein Names

interferon regulatory factor 4

  • lymphocyte-specific interferon regulatory factor

IRF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IRF4 Q15306 TLK2 Homo sapiens Q86UE8
Anti Tag CoIP
21903422
Intra
IRF4 Q15306 YTHDC2 Homo sapiens Q9H6S0
Anti Tag CoIP
21903422
Intra
IRF4 Q15306 TSEN54 Homo sapiens Q7Z6J9
Validated Y2H
32296183
Intra
IRF4 Q15306 ELP1 Homo sapiens O95163
Anti Tag CoIP
21903422
Intra
IRF4 Q15306 IRAK1 Homo sapiens P51617
Anti Tag CoIP
21903422
Intra
IRF4 Q15306 GIPC2 Homo sapiens Q8TF65
Y2H Prey Pooling
32296183
Intra
IRF4 Q15306 GIPC2 Homo sapiens Q8TF65
Validated Y2H
32296183
Intra
IRF4 Q15306 GIPC2 Homo sapiens Q8TF65
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

IRF4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82663 MUM1 Antibody (YA2408) WB, IHC-P, ICC/IF, IP, FC Human
HY-P85920 MUM1 Antibody (YA5612) IHC-P, WB, ICC/IF, ELISA Human
HY-P85971 Thyroid Peroxidase Antibody (YA5663) IHC-P, ICC/IF, ELISA Human
HY-P86042 MUM1 Antibody (YA5734) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Skin/Hair/Eye Pigmentation, Variation In, 8

  • SHEP8

  • Skin/Hair/Eye Pigmentation 8, Brown Hair

  • Skin/Hair/Eye Pigmentation 8, Fair Skin

  • Skin/Hair/Eye Pigmentation 8, Blue/Light Eye Color

  • Skin/Hair/Eye Pigmentation 8, Freckling/Sunburn

  • Pigmentation, Skin/Hair/Eye, Variation In, Type 8
Whipple Disease

  • Intestinal Lipodystrophy

  • Whipple'S Disease

  • Intestinal Lipophagic Granulomatosis

  • Secondary Non-Tropical Sprue

  • Tropheryma Whippelii Infection

  • Whipples Disease
Central Nervous System Hematologic Cancer

  • Cns Hematopoietic Tumor

  • Hematopoietic Neoplasm Of Central Nervous System

  • Central Nervous System Hematopoietic Neoplasm
Lymphatic System Cancer
Nodal Marginal Zone Lymphoma

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Monocytoid B-Cell Lymphoma
Extramedullary Plasmacytoma

  • Extraosseous Plasmacytoma

  • Plasmacytoma, Extramedullary
Lung Lymphoma

  • Pulmonary Lymphoma

  • Lymphoma Of Lung

  • Primary Lung Lymphoma
Adult Lymphoma
Testicular Lymphoma

  • Malignant Lymphoma Of Testis

  • Lymphoma Of The Testis
Breast Lymphoma

  • Lymphoma Of Breast

  • Lymphoma Of The Breast

  • Malignant Lymphoma Of Breast
Lymphatic System Disease

  • Lymphatic Diseases

  • Adenopathy

  • Lymphatic Disease

  • Disease Of Lympoid System

  • Disorder Of Lymph Node And Lymphatics

  • Disorder Of Lymphatic System

  • Disorder Of Lymphoid System

  • Lymphangiopathy

  • Lymphatic Disorder

  • Lympoid System Disease

  • Abnormality Of The Lymphatic System
Mature B-Cell Neoplasm

  • Mature B-Cell Lymphocytic Neoplasm

  • Neoplasm Of Mature B-Cells

  • Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour
Bone Lymphoma

  • Lymphoma Of Bone

  • Lymphoma Of The Bone
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Central Nervous System Lymphoma

  • Microglioma

  • Primary Cns Lymphoma

  • Cns Lymphoma

  • Primary Central Nervous System Lymphoma
Plasma Cell Leukemia

  • Plasma Cell Leukaemia

  • Leukemia, Plasma Cell

  • Plasmacytic Leukaemia

  • Plasmacytic Leukemia

  • Pcl

  • Plasma Cell Leukaemia, Nos

  • Leukemic Plasma Cell

  • Plasma Cell Leukaemia Without Mention Of Remission
Lymphoma, Mucosa-Associated Lymphoid Type

  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma
Lymphoma, Non-Hodgkin, Familial

  • Non-Hodgkin Lymphoma

  • Lymphoma, Non-Hodgkin

  • NHL

  • Lymphoma, Non-Hodgkin, Somatic

  • Lymphoma, Follicular, Somatic

  • Familial Non-Hodgkin Lymphoma

  • Lymphoma Non-Hodgkins

  • Follicular Lymphoma, Somatic

  • Lymphosarcoma

  • Non-Hodgkins Lymphoma
Marginal Zone B-Cell Lymphoma

  • Marginal Zone Lymphoma

  • Mzl

  • Mucosa-Associated Lymphoid Tissue Lymphoma
Leukocyte Disease

  • Leukocyte Disorders
Immune System Disease

  • Abnormality Of The Immune System

  • Immune System And Disorders

  • Immune System Diseases
Follicular Dendritic Cell Sarcoma

  • Dendritic Cell Sarcoma

  • Dendritic Cell Sarcoma, Follicular

  • Follicular Dendritic Cell Tumour

  • Dendritic Cell Sarcoma, Interdigitating

  • Dendritic Cell Sarcoma, Not Otherwise Specified
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Follicular Lymphoma

  • Lymphoma, Follicular

  • Lymphoma Follicular

  • Brill-Symmers' Disease

  • Large Cell Follicular Non-Hodgkin Lymphoma

  • Diffuse Follicle Centre Lymphoma

  • Diffuse Follicular Lymphoma Nos

  • Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

  • Follicular Large Cell Cleaved Or Noncleaved Lymphoma

  • Large Cell Follicular Noncleaved Lymphoma

  • Follicular Lymphoma With Or Without Diffuse Areas

  • Histiocytic Follicular Lymphoma

  • Histiocytic Nodular Lymphoma

  • Histiocytic Nodular Malignant Lymphoma

  • Large Cell Follicular Lymphoma

  • Large Cell Noncleaved Follicular Lymphoma

  • Large Cell Noncleaved Follicular Malignant Lymphoma

  • Nodular Reticulum Cell Sarcoma

  • Noncleaved Follicular Lymphoma
Basan Syndrome

  • Adermatoglyphia With Congenital Facial Milia And Acral Blisters, Digital Contractures, And Nail Abnormalities

  • Ectodermal Dysplasia, Absent Dermatoglyphic Pattern, Changes In Nails, And Simian Crease

  • Baird Syndrome

  • Absence Of Fingerprints-Congenital Milia Syndrome

  • Absence Of Fingerprints Congenital Milia

  • Absence Of Dermatoglyphics Congenital Milia

  • Absence Of Dermatoglyphics-Congenital Milia Syndrome

  • Basan-Baird Syndrome

  • BSNS

  • Adermatoglyphia, Congenital Facial Milia, Acral Blisters, Digital Contractures, Nail Abnormalities
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Waldenstroem'S Macroglobulinemia

  • Waldenstrom Macroglobulinemia

  • Macroglobulinemia Of Waldenstrom

  • Waldenström Macroglobulinemia

  • Lymphoplasmacytic Lymphoma With Igm Gammopathy

  • Lymphoplasmacytic Lymphoma

  • Waldenstrom'S Macroglobulinaemia

  • Waldenstrom'S Syndrome

  • Waldenstrom'S Macroglobulinemia

  • Wm

  • Waldenström'S Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic
Tropical Spastic Paraparesis

  • Tropical Spastic Paraplegia

  • Ham/Tsp

  • Htlv-Associated Myelopathy

  • Tropical Spastic Paralysis

  • Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis

  • Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis

  • Htlv-1-Associated Myelopathy/Tropical Spastic Paraparesis

  • Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis

  • Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis

  • Tsp

  • Paraparesis Tropical Spastic

  • Paraparesis, Tropical Spastic
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
Agammaglobulinemia

  • Hypogammaglobulinemia

  • Ighm

  • Mu Heavy Chain Deficiency

  • Mu-Heavy Chain Disease

  • Mu-Hcd

  • Mu-Chain Disease
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

  • Hgbl-Dh/Th

  • High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements

  • High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement
Rosacea

  • Erythematotelangiectatic Rosacea

  • Papulopustular Rosacea

  • Phymatous Rosacea

  • Acne Roscea

  • Acne, Erythematosa

  • Granulomatous Rosacea

  • Ocular Rosacea

  • Acne Rosacea

  • Hypertrophic Rosacea
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Mantle Cell Lymphoma

  • Lymphoma, Mantle Cell

  • Lcm

  • Mcl

  • Mantle Zone Lymphoma

  • Lymphoma Mantle-Cell

  • Lymphoma, Mantle-Cell

  • Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

  • Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

  • Diffuse Small Cleaved-Cell Lymphoma

  • Diffuse Small Cleaved Cell Malignant Lymphoma

  • Small Cleaved Cell Non-Hodgkin Lymphoma

  • Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

  • Malignant Lymphomatous Polyposis

  • Malignant Small Cell, Noncleaved, Diffuse Lymphoma

  • Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

  • Cleaved Cell Lymphoma

  • Small Cell Mantle Cell Lymphoma

  • Small Cleaved Cell Malignant Lymphoma
Selective Igg Deficiency Disease

  • Igg Deficiency

  • Immunoglobin G Subclass Deficiency

  • Selective Deficiency Of Igg

  • Selective Igg Immunodeficiency

  • Selective Immunoglobulin G Deficiency

  • Selective Immunoglobulin G Subclass Deficiency
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Neoplasms

  • Hematologic Malignancies

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
T-Cell Acute Lymphoblastic Leukemia

  • T-Cell Leukemia

  • Acute T Cell Leukemia

  • Precursor T Lymphoblastic Leukemia

  • Precursor T-Lymphoblastic Lymphoma/Leukemia

  • T Acute Lymphoblastic Leukemia

  • T-Cell Acute Lymphocytic Leukaemia

  • T-Cell Lymphoblastic Leukemia/Lymphoma

  • Leukemia T-Cell

  • Leukemia, T-Cell

  • Leukemia, Acute, Lymphoblastic, T-Cell

  • Leukemia, T-Cell Acute Lymphoblastic

  • Leukemia, Acute T-Cell

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

  • Precursor T-Cell Lymphoblastic Lymphoma

  • Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Meninges Sarcoma

  • Meningeal Sarcoma

  • Sarcoma Of Meninges

  • Meningothelial Sarcoma

  • Leptomeningeal Sarcoma
T-Cell Adult Acute Lymphocytic Leukemia

  • Acute Adult T-Cell Leukemia-Lymphoma

  • Adult Precursor T Lymphoblastic Leukemia

  • Atll

  • T-Cell Adult Acute Lymphoblastic Leukemia
Common Variable Immunodeficiency

  • Cvid

  • Common Variable Agammaglobulinemia

  • Common Variable Immune Deficiency

  • Acquired Hypogammaglobulinemia

  • Hypogamma-Globulinemia, Acquired

  • Idiopathic Immunoglobulin Deficiency

  • Primary Antibody Deficiency

  • Primary Hypogammaglobulinemia

  • Acquired Agammaglobulinemia

  • Sporadic Hypogammaglobulinemia

  • Common Variable Hypogamma-Globulinemia

  • Immunoglobulin Deficiency, Late-Onset

  • Common Variable Hypogammaglobulinemia

  • Immunodeficiency, Common Variable
Plasmablastic Lymphoma

  • Pbl

  • Immunoblastic Large-Cell Lymphoma
Bone Benign Neoplasm
Chest Wall Lymphoma

  • Chest Wall Cancer

  • Lymphoma Of Chest Wall

  • Lymphoma Of The Chest Wall

  • Malignant Neoplasm Of Chest Wall

  • Malignant Tumor Of Chest Wall
Gastric Lymphoma

  • Familial Primary Gastric Lymphoma

  • Lymphoma Of The Stomach

  • Primary Gastric Lymphoma
Multicentric Castleman Disease

  • Mcd

  • Multicentric Giant Lymph Node Hyperplasia

  • Plasmablastic Multicentric Castleman Disease

  • Pmcd

  • Idiopathic Multicentric Castleman Disease

  • Multi-Centric Castleman'S Disease

  • Idiopathic Multicentric Castleman'S Disease

  • Multicentric Plasma Cell Variant Of Castleman'S Disease

  • Hhv-8-Negative Multicentric Castleman Disease

  • Human Herpesvirus-8-Negative Multicentric Castleman Disease
Gray Zone Lymphoma

  • B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma
Myeloid Sarcoma

  • Granulocytic Sarcoma

  • Chloroma

  • Extramedullary Myeloid Tumor

  • Sarcoma, Granulocytic

  • Sarcoma Granulocytic

  • Sarcoma, Myeloid

  • Myelosarcoma

  • Myeloid Sarcoma Disease

  • Myeloid Sarcoma Nos

  • Myeloid Sarcoma Without Mention Of Remission
Childhood Lymphoma

  • Pediatric Lymphoma
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Primary Mediastinal B-Cell Lymphoma

  • Large Cell Lymphoma Of The Mediastinum

  • Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

  • Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type
Adult T-Cell Leukemia/Lymphoma

  • Adult T-Cell Leukemia

  • Atll

  • Adult T-Cell Leukaemia

  • Adult T-Cell Leukaemia/Lymphoma

  • Adult T-Cell Lymphoma

  • T Cell Leukemia Lymphoma Adult

  • Leukemia-Lymphoma, Adult T-Cell

  • Leukemia, T-Cell

  • Adult T-Cell Lymphoma/Leukemia
Lymphoplasmacytic Lymphoma

  • Waldenstrom Macroglobulinemia

  • Malignant Lymphoma - Lymphoplasmacytic

  • Waldenström Macroglobulinaemia

  • Waldenström Macroglobulinaemia Without Mention Of Remission

  • Idiopathic Macroglobulinaemia

  • Primary Macroglobulinaemia
Monoclonal Gammopathy Of Uncertain Significance

  • Monoclonal Gammopathy Of Undetermined Significance

  • Mgus

  • Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

  • Monoclonal Gammopathy Nos

  • Iga Gammopathy

  • Monoclonal Gammoglobulinopathy
Angioimmunoblastic T-Cell Lymphoma

  • Immunoblastic Lymphadenopathy

  • Lymphogranulomatosis X

  • T-Cell Lymphoma, Aild Type

  • Aitl

  • Ailt

  • Angioimmunoblastic Lymphadenopathy

  • Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia]

  • Angioimmunoblastic Lymphoma
Prion Disease

  • Spongiform Encephalopathy

  • Transmissible Spongiform Encephalopathies

  • Prion Diseases

  • Prion Disease Pathway

  • Transmissible Spongiform Encephalopathy

  • Prion Induced Disorder

  • Prion Protein Disease

  • Inherited Human Transmissible Spongiform Encephalopathies

  • Prion Protein Diseases

  • Prion-Associated Disorders

  • Prion-Induced Disorders

  • Transmissible Dementias

  • Tses

  • Human Prion Disease

  • Tse

  • Encephalopathy, Transmissible Spongiform

  • Prion Disease, Susceptibility To

  • Spongiform Encephalopathies

  • Human Transmissible Spongiform Encephalopathies, Inherited
Connective Tissue Benign Neoplasm

  • Soft Tissue Neoplasms

  • Mesenchymal Tissue Neoplasm

  • Neoplasm Of Soft Tissue

  • Neoplasm Of Soft Tissues

  • Soft Tissue Benign Neoplasm

  • Tumor Of The Soft Tissue

  • Soft Tissue Neoplasm
Hyperoxaluria, Primary, Type I

  • Primary Hyperoxaluria Type 1

  • HP1

  • Glycolic Aciduria

  • Alanine-Glyoxylate Aminotransferase Deficiency

  • Hepatic Agt Deficiency

  • Oxalosis I

  • Primary Hyperoxaluria, Type I

  • Serine:Pyruvate Aminotransferase Deficiency

  • Hyperoxaluria, Primary, Type 1

  • Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency

  • Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency

  • Serine Pyruvate Aminotransferase Deficiency

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Oxalosis 1

  • Hyperoxaluria Primary 1

  • Hyperoxaluria Primary Type I

  • Ph1

  • Primary Hyperoxaluria Type I

  • Oxalosis Type 1

  • 2-Oxoglutarate Glyoxylate Carboligase Deficiency
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Primary Hyperoxaluria

  • Hyperoxaluria

  • Hyperoxaluria, Primary

  • Oxalosis

  • Primary Oxalosis

  • Congenital Oxaluria

  • D-Glycerate Dehydrogenase Deficiency

  • Glyceric Aciduria

  • Glycolic Aciduria

  • Hepatic Agt Deficiency

  • Oxaluria, Primary

  • Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency

  • Primary Oxaluria

  • Hyperoxaluria Primary

  • Primary Hyperoxaluria Type 2

  • Primary Hyperoxaluria, Type I
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Diffuse Large B-Cell Lymphoma Activated B-Cell Type

  • Dlbcl Abc Type
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Connective Tissue Disease

  • Connective Tissue Diseases

  • Connective Tissue Disorder

  • Abnormality Of Connective Tissue

  • Disorder Of Connective Tissue

  • Connective Tissue Disorders
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Sezary'S Disease

  • Sezary Syndrome

  • Sézary Syndrome

  • Sezary'S Lymphoma

  • Sezary Disease

  • Sezary Erythroderma

  • Sezary Lymphoma
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-130800 Eragidomide 99.93% Phase 1
HY-177632 Frenlosirsen Inhibitor 96.46% Phase 1
HY-177632A Frenlosirsen sodium Inhibitor 96.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172085 SH514 99.94% Unkown
HY-172614 RK-0080552 / Unkown
HY-181957 KB528 / Unkown
HY-185697 dIRF4-2 Inhibitor / Unkown
HY-RS06908 IRF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-185698 IRF4 ligand-1 / Unkown
HY-RS16800 Irf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23241 Irf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta IRF4 VGNC VGNC:73762
Canis familiaris IRF4 VGNC VGNC:54316
Rattus norvegicus IRF4 RGD RGD:1308050
Felis catus IRF4 VGNC VGNC:67825
Mus musculus IRF4 MGD MGI:1096873
Bos taurus IRF4 VGNC VGNC:30275
Others IRF4 NCBI